Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan
Background: The lives of individuals affected by sickle cell disease are marked by painful crises sometimes accompanied by complications. Curative treatments such as bone marrow transplantation or gene therapy exist, but are not currently performed in Côte d'Ivoire. Treatment with hydroxyurea...
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| Language: | English |
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PAGEPress Publications
2024-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://www.mjhid.org/mjhid/article/view/5604 |
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| author | MIREILLE YAYO- AYE Adia Eusèbe Adjambri Boidy Kouakou Rebecca N'guessan-Blao Louis Missa Adjé Taïratou Kamagaté Vincent Yapo Duni Sawadogo |
| author_facet | MIREILLE YAYO- AYE Adia Eusèbe Adjambri Boidy Kouakou Rebecca N'guessan-Blao Louis Missa Adjé Taïratou Kamagaté Vincent Yapo Duni Sawadogo |
| author_sort | MIREILLE YAYO- AYE |
| collection | DOAJ |
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Background: The lives of individuals affected by sickle cell disease are marked by painful crises sometimes accompanied by complications. Curative treatments such as bone marrow transplantation or gene therapy exist, but are not currently performed in Côte d'Ivoire. Treatment with hydroxyurea remains an effective alternative. The aim of our study is to contribute to improving the management of children with sickle cell disease.
Methods: We conducted a prospective observational study from November 2017 to April 2019 at the at the Yopougon University Hospital. Children aged 5 to 15 years experiencing at least 3 vaso-occlusive crises (VOC) per year were included in the study after obtaining informed and written consent from their parents. Each patient received a daily dose of 15mg/kg of hydroxyurea.
Results: The mean age of the children was 9 years. More than 75% of patients were homozygous SSFA2 major sickle cell individuals. After 6 months on hydroxyurea, our study observed rates of 84.4%, 100%, and 97.8%, respectively, for the absence of vaso-occlusive crises, hospitalization, and transfusion. Biologically, from M0 to M12 the mean hemoglobin level increased significantly, from 7.24 to 8.55 g/dL; white blood cell (WBC) and platelet counts decreased; Fetal hemoglobin (Hb F) increased significantly from 10.3% to 19.7%. Biochemical parameters within normal ranges, except for a moderate treatment-related increase in transaminases.
Conclusion: The induction of fetal hemoglobin (Hb F) production through hydroxyurea intake is the primary mechanism by which hydroxyurea modifies the pathogenesis of sickle cell disease
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| format | Article |
| id | doaj-art-09675179d42f49eca7840f7206f095b5 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-09675179d42f49eca7840f7206f095b52025-02-03T00:08:30ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062024-02-0116110.4084/MJHID.2024.026Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in AbidjanMIREILLE YAYO- AYE0Adia Eusèbe Adjambri1Boidy Kouakou2Rebecca N'guessan-Blao3Louis Missa Adjé4Taïratou Kamagaté5Vincent Yapo6Duni Sawadogoa:1:{s:5:"en_US";s:108:" Department of Hematology, Faculty of Pharmacy, Felix Houphouet Boigny University, Abidjan, Côte d’Ivoire";}Department of Hematology, Faculty of Pharmacy, Felix Houphouet Boigny University, Abidjan, Côte d’IvoireDepartment of Clinical Hematology, Yopougon University Hospital, Abidjan, Côte d’IvoireDepartment of Hematology, Faculty of Pharmacy, Felix Houphouet Boigny University, Abidjan, Côte d’IvoireHematology Unit, Central Laboratory, Yopougon University Hospital, Abidjan, Côte d’IvoireDepartment of Hematology, Faculty of Pharmacy, Felix Houphouet Boigny University, Abidjan, Côte d’IvoireDepartment of Hematology, Faculty of Pharmacy, Felix Houphouet Boigny University, Abidjan, Côte d’Ivoire Background: The lives of individuals affected by sickle cell disease are marked by painful crises sometimes accompanied by complications. Curative treatments such as bone marrow transplantation or gene therapy exist, but are not currently performed in Côte d'Ivoire. Treatment with hydroxyurea remains an effective alternative. The aim of our study is to contribute to improving the management of children with sickle cell disease. Methods: We conducted a prospective observational study from November 2017 to April 2019 at the at the Yopougon University Hospital. Children aged 5 to 15 years experiencing at least 3 vaso-occlusive crises (VOC) per year were included in the study after obtaining informed and written consent from their parents. Each patient received a daily dose of 15mg/kg of hydroxyurea. Results: The mean age of the children was 9 years. More than 75% of patients were homozygous SSFA2 major sickle cell individuals. After 6 months on hydroxyurea, our study observed rates of 84.4%, 100%, and 97.8%, respectively, for the absence of vaso-occlusive crises, hospitalization, and transfusion. Biologically, from M0 to M12 the mean hemoglobin level increased significantly, from 7.24 to 8.55 g/dL; white blood cell (WBC) and platelet counts decreased; Fetal hemoglobin (Hb F) increased significantly from 10.3% to 19.7%. Biochemical parameters within normal ranges, except for a moderate treatment-related increase in transaminases. Conclusion: The induction of fetal hemoglobin (Hb F) production through hydroxyurea intake is the primary mechanism by which hydroxyurea modifies the pathogenesis of sickle cell disease https://www.mjhid.org/mjhid/article/view/5604Sickle cellHydroxyureaCôte d’Ivoire |
| spellingShingle | MIREILLE YAYO- AYE Adia Eusèbe Adjambri Boidy Kouakou Rebecca N'guessan-Blao Louis Missa Adjé Taïratou Kamagaté Vincent Yapo Duni Sawadogo Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan Mediterranean Journal of Hematology and Infectious Diseases Sickle cell Hydroxyurea Côte d’Ivoire |
| title | Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan |
| title_full | Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan |
| title_fullStr | Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan |
| title_full_unstemmed | Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan |
| title_short | Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan |
| title_sort | impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in abidjan |
| topic | Sickle cell Hydroxyurea Côte d’Ivoire |
| url | https://www.mjhid.org/mjhid/article/view/5604 |
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