Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans
Continuous deployment of antifungals in treating infections caused by dimorphic opportunistic pathogen Candida albicans has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed multidrug resistance (MDR). Despite the current understanding...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2013/240209 |
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| author | Saif Hameed Zeeshan Fatima |
| author_facet | Saif Hameed Zeeshan Fatima |
| author_sort | Saif Hameed |
| collection | DOAJ |
| description | Continuous deployment of antifungals in treating infections caused by dimorphic opportunistic pathogen Candida albicans has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed multidrug resistance (MDR). Despite the current understanding of major factors which contribute to MDR mechanisms, there are many lines of evidence suggesting that it is a complex interplay of multiple factors which may be contributed by still unknown mechanisms. Coincidentally with the increased usage of antifungal drugs, the number of reports for antifungal drug resistance has also increased which further highlights the need for understanding novel molecular mechanisms which can be explored to combat MDR, namely, ROS, iron, hypoxia, lipids, morphogenesis, and transcriptional and signaling networks. Considering the worrying evolution of MDR and significance of C. albicans being the most prevalent human fungal pathogen, this review summarizes these new regulatory mechanisms which could be exploited to prevent MDR development in C. albicans as established from recent studies. |
| format | Article |
| id | doaj-art-095eed111c0b4e15ba73f2b211331ca1 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-095eed111c0b4e15ba73f2b211331ca12025-02-03T01:21:28ZengWileyInternational Journal of Microbiology1687-918X1687-91982013-01-01201310.1155/2013/240209240209Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicansSaif Hameed0Zeeshan Fatima1Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurgaon 122413, IndiaAmity Institute of Biotechnology, Amity University Haryana, Manesar, Gurgaon 122413, IndiaContinuous deployment of antifungals in treating infections caused by dimorphic opportunistic pathogen Candida albicans has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed multidrug resistance (MDR). Despite the current understanding of major factors which contribute to MDR mechanisms, there are many lines of evidence suggesting that it is a complex interplay of multiple factors which may be contributed by still unknown mechanisms. Coincidentally with the increased usage of antifungal drugs, the number of reports for antifungal drug resistance has also increased which further highlights the need for understanding novel molecular mechanisms which can be explored to combat MDR, namely, ROS, iron, hypoxia, lipids, morphogenesis, and transcriptional and signaling networks. Considering the worrying evolution of MDR and significance of C. albicans being the most prevalent human fungal pathogen, this review summarizes these new regulatory mechanisms which could be exploited to prevent MDR development in C. albicans as established from recent studies.http://dx.doi.org/10.1155/2013/240209 |
| spellingShingle | Saif Hameed Zeeshan Fatima Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans International Journal of Microbiology |
| title | Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans |
| title_full | Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans |
| title_fullStr | Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans |
| title_full_unstemmed | Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans |
| title_short | Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans |
| title_sort | novel regulatory mechanisms of pathogenicity and virulence to combat mdr in candida albicans |
| url | http://dx.doi.org/10.1155/2013/240209 |
| work_keys_str_mv | AT saifhameed novelregulatorymechanismsofpathogenicityandvirulencetocombatmdrincandidaalbicans AT zeeshanfatima novelregulatorymechanismsofpathogenicityandvirulencetocombatmdrincandidaalbicans |