KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons
Striatal projection neurons (SPNs) process motor and cognitive information. Their activity is affected by Parkinson’s disease, in which dopamine concentration is decreased and acetylcholine concentration is increased. Acetylcholine activates muscarinic receptors in SPNs. Its main source is the choli...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/472676 |
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| author | M. Belén Pérez-Ramírez Antonio Laville Dagoberto Tapia Mariana Duhne Esther Lara-González José Bargas Elvira Galarraga |
| author_facet | M. Belén Pérez-Ramírez Antonio Laville Dagoberto Tapia Mariana Duhne Esther Lara-González José Bargas Elvira Galarraga |
| author_sort | M. Belén Pérez-Ramírez |
| collection | DOAJ |
| description | Striatal projection neurons (SPNs) process motor and cognitive information. Their activity is affected by Parkinson’s disease, in which dopamine concentration is decreased and acetylcholine concentration is increased. Acetylcholine activates muscarinic receptors in SPNs. Its main source is the cholinergic interneuron that responds with a briefer latency than SPNs during a cortical command. Therefore, an important question is whether muscarinic G-protein coupled receptors and their signaling cascades are fast enough to intervene during synaptic responses to regulate synaptic integration and firing. One of the most known voltage dependent channels regulated by muscarinic receptors is the KV7/KCNQ channel. It is not known whether these channels regulate the integration of suprathreshold corticostriatal responses. Here, we study the impact of cholinergic muscarinic modulation on the synaptic response of SPNs by regulating KV7 channels. We found that KV7 channels regulate corticostriatal synaptic integration and that this modulation occurs in the dendritic/spines compartment. In contrast, it is negligible in the somatic compartment. This modulation occurs on sub- and suprathreshold responses and lasts during the whole duration of the responses, hundreds of milliseconds, greatly altering SPNs firing properties. This modulation affected the behavior of the striatal microcircuit. |
| format | Article |
| id | doaj-art-095205aa76444ccc9f21a43d9a6654fa |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-095205aa76444ccc9f21a43d9a6654fa2025-02-03T01:22:55ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/472676472676KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal NeuronsM. Belén Pérez-Ramírez0Antonio Laville1Dagoberto Tapia2Mariana Duhne3Esther Lara-González4José Bargas5Elvira Galarraga6División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, DF, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, DF, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, DF, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, DF, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, DF, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, DF, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, DF, MexicoStriatal projection neurons (SPNs) process motor and cognitive information. Their activity is affected by Parkinson’s disease, in which dopamine concentration is decreased and acetylcholine concentration is increased. Acetylcholine activates muscarinic receptors in SPNs. Its main source is the cholinergic interneuron that responds with a briefer latency than SPNs during a cortical command. Therefore, an important question is whether muscarinic G-protein coupled receptors and their signaling cascades are fast enough to intervene during synaptic responses to regulate synaptic integration and firing. One of the most known voltage dependent channels regulated by muscarinic receptors is the KV7/KCNQ channel. It is not known whether these channels regulate the integration of suprathreshold corticostriatal responses. Here, we study the impact of cholinergic muscarinic modulation on the synaptic response of SPNs by regulating KV7 channels. We found that KV7 channels regulate corticostriatal synaptic integration and that this modulation occurs in the dendritic/spines compartment. In contrast, it is negligible in the somatic compartment. This modulation occurs on sub- and suprathreshold responses and lasts during the whole duration of the responses, hundreds of milliseconds, greatly altering SPNs firing properties. This modulation affected the behavior of the striatal microcircuit.http://dx.doi.org/10.1155/2015/472676 |
| spellingShingle | M. Belén Pérez-Ramírez Antonio Laville Dagoberto Tapia Mariana Duhne Esther Lara-González José Bargas Elvira Galarraga KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons Neural Plasticity |
| title | KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons |
| title_full | KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons |
| title_fullStr | KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons |
| title_full_unstemmed | KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons |
| title_short | KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons |
| title_sort | kv7 channels regulate firing during synaptic integration in gabaergic striatal neurons |
| url | http://dx.doi.org/10.1155/2015/472676 |
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