Synthesis and Biological Evaluation of New <i>cis</i>-Restricted Triazole Analogues of Combretastatin A-4

Synthesis and Biological Evaluation of New <i>cis</i>-Restricted Triazole Analogues of Combretastatin A-4

The natural products combretastatins A-1 and A-4 are potent antimitotic and vascular-disrupting agents through their binding at the colchicine site in tubulin. However, these compounds suffer from a low water solubility and a tendency to isomerize to the inactive <i>trans</i> stilbenes....

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Bibliographic Details
Main Authors: Lidia Prieto, Daniel Gaviña, Marcos Escolano, María Cánovas-Belchí, María Sánchez-Roselló, Carlos del Pozo, Eva Falomir, Santiago Díaz-Oltra
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
cancer
tubulin
antimitotics
combretastatin A-4
triazoles
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/30/2/317
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