Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential
Breast milk is a fluid of vital importance during the first stages of life of the newborn since, in addition to providing nutrients, it also contains cells and molecules of the immune system, which protect the neonate from infection and, at the same time, modulate the establishment of the microbiota...
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MDPI AG
2025-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/1/115 |
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| author | Alba Soledad Aquino-Domínguez María de los Ángeles Romero-Tlalolini Honorio Torres-Aguilar Juan Carlos Rodríguez-Alba Lucia Lourdes Martínez-Martínez Francisco Javier Sánchez-Peña María Teresa Hernández-Huerta Jesús Elizarrarás-Rivas Gabriela Tapia-Pastrana Melisa Gómez-López Elsa Cruz-Martínez Uriel Eleazar Hernández-Corrales Sergio Roberto Aguilar-Ruiz |
| author_facet | Alba Soledad Aquino-Domínguez María de los Ángeles Romero-Tlalolini Honorio Torres-Aguilar Juan Carlos Rodríguez-Alba Lucia Lourdes Martínez-Martínez Francisco Javier Sánchez-Peña María Teresa Hernández-Huerta Jesús Elizarrarás-Rivas Gabriela Tapia-Pastrana Melisa Gómez-López Elsa Cruz-Martínez Uriel Eleazar Hernández-Corrales Sergio Roberto Aguilar-Ruiz |
| author_sort | Alba Soledad Aquino-Domínguez |
| collection | DOAJ |
| description | Breast milk is a fluid of vital importance during the first stages of life of the newborn since, in addition to providing nutrients, it also contains cells and molecules of the immune system, which protect the neonate from infection and, at the same time, modulate the establishment of the microbiota. Bactericidal/permeability-increasing protein (BPI) is relevant in preventing disease and sepsis in neonates. Therefore, the following work aimed to demonstrate the presence of BPI in the different stages of breast milk and its possible immune functions. Our results demonstrate for the first time the presence of soluble BPI and leukocytes and epithelial cells containing it, primarily in the colostrum stage. Using BPI at concentrations typical of colostrum, we observed that it reduces the growth of two distinct <i>E. coli</i> strains, enhances the uptake of these bacteria by monocytes, and suppresses the secretion of the proinflammatory cytokine interleukin (IL)-8 in infected intestinal cells. These findings suggest that BPI transferred via colostrum from mother to newborn may play a significant role in providing antimicrobial and anti-inflammatory protection during the early stages of life. |
| format | Article |
| id | doaj-art-09407e4c733b4c28b92cbc828835c179 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-09407e4c733b4c28b92cbc828835c1792025-01-24T13:42:42ZengMDPI AGMicroorganisms2076-26072025-01-0113111510.3390/microorganisms13010115Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune PotentialAlba Soledad Aquino-Domínguez0María de los Ángeles Romero-Tlalolini1Honorio Torres-Aguilar2Juan Carlos Rodríguez-Alba3Lucia Lourdes Martínez-Martínez4Francisco Javier Sánchez-Peña5María Teresa Hernández-Huerta6Jesús Elizarrarás-Rivas7Gabriela Tapia-Pastrana8Melisa Gómez-López9Elsa Cruz-Martínez10Uriel Eleazar Hernández-Corrales11Sergio Roberto Aguilar-Ruiz12Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoConsejo Nacional de Humanidades, Ciencias y Tecnologías, Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoFacultad de Ciencias Químicas, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoUnidad de Neuroinmunología y Neurooncología, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México 14269, MexicoFacultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoFacultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoConsejo Nacional de Humanidades, Ciencias y Tecnologías, Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoFacultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoServicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Hospital del Alta Especialidad de Oaxaca, San Bartolo Coyotepec 71294, Oaxaca, MexicoHospital General “Aurelio Valdivieso MD”, Secretaria de Salud (SS), Oaxaca 68000, Oaxaca, MexicoHospital General “Aurelio Valdivieso MD”, Secretaria de Salud (SS), Oaxaca 68000, Oaxaca, MexicoHospital Comunitario Nejapa de Madero, Nejapa de Madero 70531, Oaxaca, MexicoFacultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68120, Oaxaca, MexicoBreast milk is a fluid of vital importance during the first stages of life of the newborn since, in addition to providing nutrients, it also contains cells and molecules of the immune system, which protect the neonate from infection and, at the same time, modulate the establishment of the microbiota. Bactericidal/permeability-increasing protein (BPI) is relevant in preventing disease and sepsis in neonates. Therefore, the following work aimed to demonstrate the presence of BPI in the different stages of breast milk and its possible immune functions. Our results demonstrate for the first time the presence of soluble BPI and leukocytes and epithelial cells containing it, primarily in the colostrum stage. Using BPI at concentrations typical of colostrum, we observed that it reduces the growth of two distinct <i>E. coli</i> strains, enhances the uptake of these bacteria by monocytes, and suppresses the secretion of the proinflammatory cytokine interleukin (IL)-8 in infected intestinal cells. These findings suggest that BPI transferred via colostrum from mother to newborn may play a significant role in providing antimicrobial and anti-inflammatory protection during the early stages of life.https://www.mdpi.com/2076-2607/13/1/115breast milkbactericidal/permeability-increasing protein (BPI)colostrumantimicrobial functionanti-inflammatory functionepithelial cells |
| spellingShingle | Alba Soledad Aquino-Domínguez María de los Ángeles Romero-Tlalolini Honorio Torres-Aguilar Juan Carlos Rodríguez-Alba Lucia Lourdes Martínez-Martínez Francisco Javier Sánchez-Peña María Teresa Hernández-Huerta Jesús Elizarrarás-Rivas Gabriela Tapia-Pastrana Melisa Gómez-López Elsa Cruz-Martínez Uriel Eleazar Hernández-Corrales Sergio Roberto Aguilar-Ruiz Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential Microorganisms breast milk bactericidal/permeability-increasing protein (BPI) colostrum antimicrobial function anti-inflammatory function epithelial cells |
| title | Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential |
| title_full | Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential |
| title_fullStr | Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential |
| title_full_unstemmed | Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential |
| title_short | Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential |
| title_sort | bactericidal permeability increasing protein bpi a novel antimicrobial molecule in human breast milk with immune potential |
| topic | breast milk bactericidal/permeability-increasing protein (BPI) colostrum antimicrobial function anti-inflammatory function epithelial cells |
| url | https://www.mdpi.com/2076-2607/13/1/115 |
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