Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage
It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn. In fact, despite intricate internal neuroplasticity and diverse external sympto...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/2162105 |
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| _version_ | 1832545828589273088 |
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| author | Yi Zhao Qiang Song Xinyi Li Chunyan Li |
| author_facet | Yi Zhao Qiang Song Xinyi Li Chunyan Li |
| author_sort | Yi Zhao |
| collection | DOAJ |
| description | It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn. In fact, despite intricate internal neuroplasticity and diverse external symptoms, several classical injury models provide a feasible path to locate responses to different peripheral cochlear lesions. In these cases, hair cell damage may lead to considerable hyperactivity in the central auditory pathways, mediated by a reduction in inhibition, which may underlie some clinical symptoms associated with hearing loss, such as tinnitus. Homeostatic plasticity, the most discussed and acknowledged mechanism in recent years, is most likely responsible for excited central activity following cochlear damage. |
| format | Article |
| id | doaj-art-09376e60914a45118c3b62829a0aef9e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-09376e60914a45118c3b62829a0aef9e2025-02-03T07:24:37ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/21621052162105Neural Hyperactivity of the Central Auditory System in Response to Peripheral DamageYi Zhao0Qiang Song1Xinyi Li2Chunyan Li3Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaDepartment of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaDepartment of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaDepartment of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaIt is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn. In fact, despite intricate internal neuroplasticity and diverse external symptoms, several classical injury models provide a feasible path to locate responses to different peripheral cochlear lesions. In these cases, hair cell damage may lead to considerable hyperactivity in the central auditory pathways, mediated by a reduction in inhibition, which may underlie some clinical symptoms associated with hearing loss, such as tinnitus. Homeostatic plasticity, the most discussed and acknowledged mechanism in recent years, is most likely responsible for excited central activity following cochlear damage.http://dx.doi.org/10.1155/2016/2162105 |
| spellingShingle | Yi Zhao Qiang Song Xinyi Li Chunyan Li Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage Neural Plasticity |
| title | Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage |
| title_full | Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage |
| title_fullStr | Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage |
| title_full_unstemmed | Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage |
| title_short | Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage |
| title_sort | neural hyperactivity of the central auditory system in response to peripheral damage |
| url | http://dx.doi.org/10.1155/2016/2162105 |
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