The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atheroscler...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/837250 |
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| _version_ | 1832552615044448256 |
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| author | Samuel García Carmen Conde |
| author_facet | Samuel García Carmen Conde |
| author_sort | Samuel García |
| collection | DOAJ |
| description | Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. In recent years, we have studied the role of PARP-1 in rheumatoid arthritis, as have other researchers, and the results have shown that PARP-1 has an important function in the development of this disease. This review summarizes current knowledge on the effects of PARP-1 in rheumatoid arthritis. |
| format | Article |
| id | doaj-art-0931778c69f841cea821c86dded52215 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0931778c69f841cea821c86dded522152025-02-03T05:58:09ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/837250837250The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid ArthritisSamuel García0Carmen Conde1Laboratory of Translational Immunology and Department of Rheumatology and Clinical Immunology, University Medical Center, Lundlaan 6, 3508 GA Utrecht, NetherlandsLaboratorio de Investigación 8, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago de Compostela (CHUS), SERGAS, Travesia da Choupana s/n, 15706 Santiago de Compostela, SpainPoly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. In recent years, we have studied the role of PARP-1 in rheumatoid arthritis, as have other researchers, and the results have shown that PARP-1 has an important function in the development of this disease. This review summarizes current knowledge on the effects of PARP-1 in rheumatoid arthritis.http://dx.doi.org/10.1155/2015/837250 |
| spellingShingle | Samuel García Carmen Conde The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis Mediators of Inflammation |
| title | The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis |
| title_full | The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis |
| title_fullStr | The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis |
| title_full_unstemmed | The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis |
| title_short | The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis |
| title_sort | role of poly adp ribose polymerase 1 in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2015/837250 |
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