Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration
Abstract Microneedles (MNs) have been extensively used as transdermal therapeutics delivery devices since 1998 due to their capacity to penetrate physiological barriers with minimal invasiveness. Recent advances demonstrate the potential of MNs in improving diverse tissue regeneration when integrate...
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BMC
2025-05-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03383-1 |
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| author | Churong Xu Fei Wu Zhouyi Duan Bhavana Rajbanshi Yuxin Qi Jiaming Qin Liming Dai Chaozong Liu Tuo Jin Bingjun Zhang Xiaoling Zhang |
| author_facet | Churong Xu Fei Wu Zhouyi Duan Bhavana Rajbanshi Yuxin Qi Jiaming Qin Liming Dai Chaozong Liu Tuo Jin Bingjun Zhang Xiaoling Zhang |
| author_sort | Churong Xu |
| collection | DOAJ |
| description | Abstract Microneedles (MNs) have been extensively used as transdermal therapeutics delivery devices since 1998 due to their capacity to penetrate physiological barriers with minimal invasiveness. Recent advances demonstrate the potential of MNs in improving diverse tissue regeneration when integrated with nanometer-sized therapeutics or sensors. This synergistic strategy can enhance drug delivery efficiency and therapeutic outcomes, and enable precise and personalized therapies through real-time monitoring of the repair process. In this review, we discuss how optimized MNs (through adjustments in geometry, material properties, and modular structure), when combined with dimension- and composition-specific nanomaterials, enhance tissue regeneration efficiency. Moreover, integrating stimuli-responsive nanotherapeutics or nanosensors into MNs for spatiotemporal-controlled and targeted drug release, physiotherapy effects, and intelligent monitoring is systematically outlined. Furthermore, we summarize therapeutic applications of nanotherapeutics-MN platforms in various soft and hard tissues, including skin, hair follicles (HF), cornea, joint, tendons, sciatic nerves, spinal cord, periodontium, oral mucosa, myocardium, endometrium, bone and intervertebral discs (IVD). Notably, recent attempts using nanosensor-MN platforms as smart wearable devices for monitoring damaged tissues via interstitial fluid (ISF) extraction and biomarker sensing are analyzed. This review potentially provides tissue regeneration practitioners/researchers with a cross-disciplinary perspective and inspiration. Graphical abstract |
| format | Article |
| id | doaj-art-09303a91d49c46d788c5aff5eae36fab |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-09303a91d49c46d788c5aff5eae36fab2025-08-20T03:52:24ZengBMCJournal of Nanobiotechnology1477-31552025-05-0123113410.1186/s12951-025-03383-1Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regenerationChurong Xu0Fei Wu1Zhouyi Duan2Bhavana Rajbanshi3Yuxin Qi4Jiaming Qin5Liming Dai6Chaozong Liu7Tuo Jin8Bingjun Zhang9Xiaoling Zhang10Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineSchool of Pharmacy, Shanghai Jiao Tong UniversityDepartment of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Dermatology and Venereology, Tongji University School of MedicineCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical UniversityDepartment of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineInstitute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic HospitalSchool of Pharmacy, Shanghai Jiao Tong UniversityDepartment of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract Microneedles (MNs) have been extensively used as transdermal therapeutics delivery devices since 1998 due to their capacity to penetrate physiological barriers with minimal invasiveness. Recent advances demonstrate the potential of MNs in improving diverse tissue regeneration when integrated with nanometer-sized therapeutics or sensors. This synergistic strategy can enhance drug delivery efficiency and therapeutic outcomes, and enable precise and personalized therapies through real-time monitoring of the repair process. In this review, we discuss how optimized MNs (through adjustments in geometry, material properties, and modular structure), when combined with dimension- and composition-specific nanomaterials, enhance tissue regeneration efficiency. Moreover, integrating stimuli-responsive nanotherapeutics or nanosensors into MNs for spatiotemporal-controlled and targeted drug release, physiotherapy effects, and intelligent monitoring is systematically outlined. Furthermore, we summarize therapeutic applications of nanotherapeutics-MN platforms in various soft and hard tissues, including skin, hair follicles (HF), cornea, joint, tendons, sciatic nerves, spinal cord, periodontium, oral mucosa, myocardium, endometrium, bone and intervertebral discs (IVD). Notably, recent attempts using nanosensor-MN platforms as smart wearable devices for monitoring damaged tissues via interstitial fluid (ISF) extraction and biomarker sensing are analyzed. This review potentially provides tissue regeneration practitioners/researchers with a cross-disciplinary perspective and inspiration. Graphical abstracthttps://doi.org/10.1186/s12951-025-03383-1MicroneedleNanotherapeuticsNanosensorTissue regenerationBiomarkerMonitor |
| spellingShingle | Churong Xu Fei Wu Zhouyi Duan Bhavana Rajbanshi Yuxin Qi Jiaming Qin Liming Dai Chaozong Liu Tuo Jin Bingjun Zhang Xiaoling Zhang Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration Journal of Nanobiotechnology Microneedle Nanotherapeutics Nanosensor Tissue regeneration Biomarker Monitor |
| title | Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration |
| title_full | Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration |
| title_fullStr | Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration |
| title_full_unstemmed | Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration |
| title_short | Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration |
| title_sort | microneedle aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration |
| topic | Microneedle Nanotherapeutics Nanosensor Tissue regeneration Biomarker Monitor |
| url | https://doi.org/10.1186/s12951-025-03383-1 |
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