Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis

PurposeWe describe an unusual case of a rapidly progressive pilomatricoma along the left brow, which was initially misdiagnosed and treated as preseptal cellulitis. Although rare, pilomatricomas and other adnexal tumors should be considered in the differential diagnosis of a growing mass near the br...

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Main Authors: Rahul Kumar, Jane Z. Spadaro, Alon Kahana
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Ophthalmology
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Online Access:https://www.frontiersin.org/articles/10.3389/fopht.2025.1503693/full
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author Rahul Kumar
Jane Z. Spadaro
Jane Z. Spadaro
Alon Kahana
Alon Kahana
Alon Kahana
author_facet Rahul Kumar
Jane Z. Spadaro
Jane Z. Spadaro
Alon Kahana
Alon Kahana
Alon Kahana
author_sort Rahul Kumar
collection DOAJ
description PurposeWe describe an unusual case of a rapidly progressive pilomatricoma along the left brow, which was initially misdiagnosed and treated as preseptal cellulitis. Although rare, pilomatricomas and other adnexal tumors should be considered in the differential diagnosis of a growing mass near the brow.Case presentationA 29-year-old male presented to the emergency department with a progressively enlarging left brow lesion, initially noted 3 weeks prior. Exam revealed an erythematous left subbrow mass that measured 2.5 x 2 cm, with resultant mechanical ptosis. The lesion was initially misdiagnosed and treated as preseptal cellulitis, with concern for abscess. The patient ultimately underwent excisional biopsy of the lesion and pathology revealed pilomatricoma.ConclusionsPilomatricoma has similarities to more common skin lesions. Lack of pain or tenderness are important clues against an infectious or inflammatory etiology. Complete surgical excision is therapeutic and allows for diagnostic confirmation. Histopathology is required to rule out pilomatrix carcinoma, a malignant variant.
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spelling doaj-art-09182d71696d44feb5d6bd3188c500442025-01-23T06:56:09ZengFrontiers Media S.A.Frontiers in Ophthalmology2674-08262025-01-01510.3389/fopht.2025.15036931503693Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitisRahul Kumar0Jane Z. Spadaro1Jane Z. Spadaro2Alon Kahana3Alon Kahana4Alon Kahana5College of Medicine, Northeast Ohio Medical University, Rootstown, OH, United StatesKahana Oculoplastic and Orbital Surgery, Livonia, MI, United StatesBeaumont Eye Institute, William Beaumont Hospital, Royal Oak, MI, United StatesKahana Oculoplastic and Orbital Surgery, Livonia, MI, United StatesBeaumont Eye Institute, William Beaumont Hospital, Royal Oak, MI, United StatesDepartment of Ophthalmology, Oakland University William Beaumont School of Medicine, Rochester, MI, United StatesPurposeWe describe an unusual case of a rapidly progressive pilomatricoma along the left brow, which was initially misdiagnosed and treated as preseptal cellulitis. Although rare, pilomatricomas and other adnexal tumors should be considered in the differential diagnosis of a growing mass near the brow.Case presentationA 29-year-old male presented to the emergency department with a progressively enlarging left brow lesion, initially noted 3 weeks prior. Exam revealed an erythematous left subbrow mass that measured 2.5 x 2 cm, with resultant mechanical ptosis. The lesion was initially misdiagnosed and treated as preseptal cellulitis, with concern for abscess. The patient ultimately underwent excisional biopsy of the lesion and pathology revealed pilomatricoma.ConclusionsPilomatricoma has similarities to more common skin lesions. Lack of pain or tenderness are important clues against an infectious or inflammatory etiology. Complete surgical excision is therapeutic and allows for diagnostic confirmation. Histopathology is required to rule out pilomatrix carcinoma, a malignant variant.https://www.frontiersin.org/articles/10.3389/fopht.2025.1503693/fullorbital tumorpreseptal cellulitesfolliculomashair follicle tumorbrow and lid reconstruction
spellingShingle Rahul Kumar
Jane Z. Spadaro
Jane Z. Spadaro
Alon Kahana
Alon Kahana
Alon Kahana
Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis
Frontiers in Ophthalmology
orbital tumor
preseptal cellulites
folliculomas
hair follicle tumor
brow and lid reconstruction
title Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis
title_full Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis
title_fullStr Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis
title_full_unstemmed Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis
title_short Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis
title_sort case report periorbital pilomatricoma a rare benign skin tumor misdiagnosed as cellulitis
topic orbital tumor
preseptal cellulites
folliculomas
hair follicle tumor
brow and lid reconstruction
url https://www.frontiersin.org/articles/10.3389/fopht.2025.1503693/full
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