The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells
The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) has an important role in modulating immunity and homeostasis. The production of IFN-γ by effector T cells is suppressed by α-MSH, while TGF-β production is promoted in the same cells. Such α-MSH-treated T cells have immune regulatory acti...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/246856 |
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| author | Andrew W. Taylor Darren J. Lee |
| author_facet | Andrew W. Taylor Darren J. Lee |
| author_sort | Andrew W. Taylor |
| collection | DOAJ |
| description | The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) has an important role in modulating immunity and homeostasis. The production of IFN-γ by effector T cells is suppressed by α-MSH, while TGF-β production is promoted in the same cells. Such α-MSH-treated T cells have immune regulatory activity and suppress hypersensitivity, autoimmune diseases, and graft rejection. Previous characterizations of the α-MSH-induced Treg cells showed that the cells are CD4+ T cells expressing the same levels of CD25 as effector T cells. Therefore, we further analyzed the α-MSH-induced Treg cells for expression of effector and regulatory T-cell markers. Also, we examined the potential for α-MSH-induced Treg cells to be from the effector T-cell population. We found that the α-MSH-induced Treg cells are CD25+ CD4+ T cells that share similar surface markers as effector T cells, except that they express on their surface LAP. Also, the α-MSH treatment augments FoxP3 message in the effector T cells, and α-MSH induction of regulatory activity was limited to the effector CD25+ T-cell population. Therefore, α-MSH converts effector T cells into Treg cells, which suppress immunity targeting specific antigens and tissues. |
| format | Article |
| id | doaj-art-08fe905ba2124346b4e0846afaf1eabf |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-08fe905ba2124346b4e0846afaf1eabf2025-02-03T05:45:17ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/246856246856The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg CellsAndrew W. Taylor0Darren J. Lee1Department of Ophthalmology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USADepartment of Ophthalmology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USAThe neuropeptide alpha-melanocyte stimulating hormone (α-MSH) has an important role in modulating immunity and homeostasis. The production of IFN-γ by effector T cells is suppressed by α-MSH, while TGF-β production is promoted in the same cells. Such α-MSH-treated T cells have immune regulatory activity and suppress hypersensitivity, autoimmune diseases, and graft rejection. Previous characterizations of the α-MSH-induced Treg cells showed that the cells are CD4+ T cells expressing the same levels of CD25 as effector T cells. Therefore, we further analyzed the α-MSH-induced Treg cells for expression of effector and regulatory T-cell markers. Also, we examined the potential for α-MSH-induced Treg cells to be from the effector T-cell population. We found that the α-MSH-induced Treg cells are CD25+ CD4+ T cells that share similar surface markers as effector T cells, except that they express on their surface LAP. Also, the α-MSH treatment augments FoxP3 message in the effector T cells, and α-MSH induction of regulatory activity was limited to the effector CD25+ T-cell population. Therefore, α-MSH converts effector T cells into Treg cells, which suppress immunity targeting specific antigens and tissues.http://dx.doi.org/10.1155/2011/246856 |
| spellingShingle | Andrew W. Taylor Darren J. Lee The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells Journal of Transplantation |
| title | The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells |
| title_full | The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells |
| title_fullStr | The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells |
| title_full_unstemmed | The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells |
| title_short | The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells |
| title_sort | alpha melanocyte stimulating hormone induces conversion of effector t cells into treg cells |
| url | http://dx.doi.org/10.1155/2011/246856 |
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