Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucoma
Background: Glaucoma is a chronic, progressive optic neuropathy caused by a group of ocular conditions which lead to damage of the optic nerve with progressive diminution of vision. Medical management is currently the primary line of treatment in primary open-angle glaucoma (POAG). Aim: The aim of t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Clinical Ophthalmology and Research |
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| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_59_24 |
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| author | Anushree Dayanand Sushma Muraraiah S. Karthik Raja Nishat Sultana Khayoom |
| author_facet | Anushree Dayanand Sushma Muraraiah S. Karthik Raja Nishat Sultana Khayoom |
| author_sort | Anushree Dayanand |
| collection | DOAJ |
| description | Background:
Glaucoma is a chronic, progressive optic neuropathy caused by a group of ocular conditions which lead to damage of the optic nerve with progressive diminution of vision. Medical management is currently the primary line of treatment in primary open-angle glaucoma (POAG).
Aim:
The aim of this study was to determine the pattern of pharmacotherapy and the adverse drug reactions (ADRs) and factors associated with clinical outcomes in patients with POAG.
Materials and Methods:
This cross-sectional study involved 100 patients diagnosed with POAG satisfying inclusion criteria. The demographic, clinical, and treatment data along with ADRs to antiglaucoma drugs were noted. Descriptive statistics and Chi-square test were used to analyze the data.
Results:
The most commonly prescribed antiglaucoma medications were timolol (76%) and latanoprost (31%). The most common fixed-dose combination (FDC) prescribed was timolol + brimonidine (20%). Thirty-seven percentage of the patients needed switch over from initial medications and 16% needed add-on therapy by the end of 1 year. The most common ADR was redness of the eye (30.5%). The target intraocular pressure (IOP) was achieved in 65% of the patients after 3 months of treatment. It was found that target IOP was associated with gender and residence.
Conclusion:
Timolol was the most commonly prescribed antiglaucoma medication though it reported the highest number of ADRs. Timolol + brimonidine is the most commonly prescribed FDC. The target IOP was achieved in two-thirds of the POAG patients. |
| format | Article |
| id | doaj-art-08f2b085d45c44349884ff7095dd4b5b |
| institution | Kabale University |
| issn | 2320-3897 2320-3900 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj-art-08f2b085d45c44349884ff7095dd4b5b2025-02-06T06:38:52ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972320-39002025-01-01131283310.4103/jcor.jcor_59_24Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucomaAnushree DayanandSushma MuraraiahS. Karthik RajaNishat Sultana KhayoomBackground: Glaucoma is a chronic, progressive optic neuropathy caused by a group of ocular conditions which lead to damage of the optic nerve with progressive diminution of vision. Medical management is currently the primary line of treatment in primary open-angle glaucoma (POAG). Aim: The aim of this study was to determine the pattern of pharmacotherapy and the adverse drug reactions (ADRs) and factors associated with clinical outcomes in patients with POAG. Materials and Methods: This cross-sectional study involved 100 patients diagnosed with POAG satisfying inclusion criteria. The demographic, clinical, and treatment data along with ADRs to antiglaucoma drugs were noted. Descriptive statistics and Chi-square test were used to analyze the data. Results: The most commonly prescribed antiglaucoma medications were timolol (76%) and latanoprost (31%). The most common fixed-dose combination (FDC) prescribed was timolol + brimonidine (20%). Thirty-seven percentage of the patients needed switch over from initial medications and 16% needed add-on therapy by the end of 1 year. The most common ADR was redness of the eye (30.5%). The target intraocular pressure (IOP) was achieved in 65% of the patients after 3 months of treatment. It was found that target IOP was associated with gender and residence. Conclusion: Timolol was the most commonly prescribed antiglaucoma medication though it reported the highest number of ADRs. Timolol + brimonidine is the most commonly prescribed FDC. The target IOP was achieved in two-thirds of the POAG patients.https://journals.lww.com/10.4103/jcor.jcor_59_24adverse drug reactionsclinical outcomesfactorspharmacotherapyprimary open-angle glaucoma |
| spellingShingle | Anushree Dayanand Sushma Muraraiah S. Karthik Raja Nishat Sultana Khayoom Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucoma Journal of Clinical Ophthalmology and Research adverse drug reactions clinical outcomes factors pharmacotherapy primary open-angle glaucoma |
| title | Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucoma |
| title_full | Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucoma |
| title_fullStr | Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucoma |
| title_full_unstemmed | Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucoma |
| title_short | Pharmacotherapy, adverse drug reactions, and factors associated with clinical outcome in primary open-angle glaucoma |
| title_sort | pharmacotherapy adverse drug reactions and factors associated with clinical outcome in primary open angle glaucoma |
| topic | adverse drug reactions clinical outcomes factors pharmacotherapy primary open-angle glaucoma |
| url | https://journals.lww.com/10.4103/jcor.jcor_59_24 |
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