A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women
Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th gestational week (GW). It is a significant cause of maternal and fetal perinatal morbidity and mortality during pregnancy. There is increasing evidence suggesting that PE is due to an impaired balance between maternal...
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| Format: | Article |
| Language: | English |
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Medical University - Pleven
2019-12-01
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| Series: | Journal of Biomedical & Clinical Research |
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| Online Access: | https://jbcr.arphahub.com/article/34553/download/pdf/ |
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| author | Polina Vasileva Angel Yordanov Valentina Mazneykova Adelaida Ruseva Dobromir Dimitrov |
| author_facet | Polina Vasileva Angel Yordanov Valentina Mazneykova Adelaida Ruseva Dobromir Dimitrov |
| author_sort | Polina Vasileva |
| collection | DOAJ |
| description | Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th gestational week (GW). It is a significant cause of maternal and fetal perinatal morbidity and mortality during pregnancy. There is increasing evidence suggesting that PE is due to an impaired balance between maternal placental angiogenic and antiangiogenic factors that harm maternal vascular endothelium. The study aimed to assess the clinical and financial aspects of introducing into practice the soluble fms-like tyrosine kinase (sFlt-1) to placental growth factor (PlGF) ratio test to improve the management of preeclampsia and adverse pregnancy outcome, intrauterine growth retardation, iatrogenic prematurity, and placental abruption.We report a case study in which we used the sFlt-1/PlGF ratio in the management of a high-risk pregnancy. Unnecessary hospitalization was avoided, and the patient was managed appropriately. |
| format | Article |
| id | doaj-art-08e5708b33704d24bb8b2ceebbb34b53 |
| institution | Kabale University |
| issn | 1313-9053 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-08e5708b33704d24bb8b2ceebbb34b532025-08-20T03:35:25ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532019-12-0112216216510.2478/jbcr-2019-002434553A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive WomenPolina VasilevaAngel YordanovValentina MazneykovaAdelaida RusevaDobromir DimitrovPreeclampsia (PE) is characterized by hypertension and proteinuria after the 20th gestational week (GW). It is a significant cause of maternal and fetal perinatal morbidity and mortality during pregnancy. There is increasing evidence suggesting that PE is due to an impaired balance between maternal placental angiogenic and antiangiogenic factors that harm maternal vascular endothelium. The study aimed to assess the clinical and financial aspects of introducing into practice the soluble fms-like tyrosine kinase (sFlt-1) to placental growth factor (PlGF) ratio test to improve the management of preeclampsia and adverse pregnancy outcome, intrauterine growth retardation, iatrogenic prematurity, and placental abruption.We report a case study in which we used the sFlt-1/PlGF ratio in the management of a high-risk pregnancy. Unnecessary hospitalization was avoided, and the patient was managed appropriately.https://jbcr.arphahub.com/article/34553/download/pdf/preeclampsiasFlt-1/PlGF ratioadverse pregnancy |
| spellingShingle | Polina Vasileva Angel Yordanov Valentina Mazneykova Adelaida Ruseva Dobromir Dimitrov A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women Journal of Biomedical & Clinical Research preeclampsia sFlt-1/PlGF ratio adverse pregnancy |
| title | A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women |
| title_full | A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women |
| title_fullStr | A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women |
| title_full_unstemmed | A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women |
| title_short | A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women |
| title_sort | case report of influence of free tyrosine kinase placental growth factor sflt 1 plgf ratio test for preeclampsia on clinical decision making in screening positive women |
| topic | preeclampsia sFlt-1/PlGF ratio adverse pregnancy |
| url | https://jbcr.arphahub.com/article/34553/download/pdf/ |
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