Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery
Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reporte...
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MDPI AG
2025-02-01
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| Series: | Magnetochemistry |
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| author | Amrita Das Prateep Sengupta Shreya Chatterjee Jasmina Khanam Pranab Kumar Mondal Eder Lilia Romero Anton M. Manakhov Sabu Thomas Syed Mahmood Kajal Ghosal |
| author_facet | Amrita Das Prateep Sengupta Shreya Chatterjee Jasmina Khanam Pranab Kumar Mondal Eder Lilia Romero Anton M. Manakhov Sabu Thomas Syed Mahmood Kajal Ghosal |
| author_sort | Amrita Das |
| collection | DOAJ |
| description | Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug delivery system for aceclofenac, a model drug. The physical and chemical characteristics of both the prepared magnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughly examined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the prepared MNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed light on the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the development of magnetic nanoparticle-based drug carriers, paving the way for enhanced drug delivery strategies in the field of pharmaceutical sciences. |
| format | Article |
| id | doaj-art-08e1f7b26db04c1ba4ae0f6ad9d318a1 |
| institution | DOAJ |
| issn | 2312-7481 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Magnetochemistry |
| spelling | doaj-art-08e1f7b26db04c1ba4ae0f6ad9d318a12025-08-20T02:44:42ZengMDPI AGMagnetochemistry2312-74812025-02-011121410.3390/magnetochemistry11020014Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug DeliveryAmrita Das0Prateep Sengupta1Shreya Chatterjee2Jasmina Khanam3Pranab Kumar Mondal4Eder Lilia Romero5Anton M. Manakhov6Sabu Thomas7Syed Mahmood8Kajal Ghosal9Nanofabrication and Tissue Engineering Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaNanofabrication and Tissue Engineering Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaNanofabrication and Tissue Engineering Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaNanofabrication and Tissue Engineering Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaMicrofluidics and Microscale Transport Processes Laboratory, Department of Mechanical Engineering, Indian Institute of Technology, Guwahati 781039, IndiaNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, ArgentinaResearch Institute of Clinical and Experimental Lymphology—Branch of the ICG SB RAS, 2 Timakova St., Novosibirsk 630060, RussiaInternational and Inter University Centre for Nanoscience and Nanotechnology (IIUCNN), Mahatma Gandhi University, Kottayam 686560, IndiaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, MalaysiaNanofabrication and Tissue Engineering Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaIron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug delivery system for aceclofenac, a model drug. The physical and chemical characteristics of both the prepared magnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughly examined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the prepared MNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed light on the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the development of magnetic nanoparticle-based drug carriers, paving the way for enhanced drug delivery strategies in the field of pharmaceutical sciences.https://www.mdpi.com/2312-7481/11/2/14magnetic nanoparticlesodium alginateaceclofenacvibrating sample magnetometrytargeted therapeutic |
| spellingShingle | Amrita Das Prateep Sengupta Shreya Chatterjee Jasmina Khanam Pranab Kumar Mondal Eder Lilia Romero Anton M. Manakhov Sabu Thomas Syed Mahmood Kajal Ghosal Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery Magnetochemistry magnetic nanoparticle sodium alginate aceclofenac vibrating sample magnetometry targeted therapeutic |
| title | Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery |
| title_full | Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery |
| title_fullStr | Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery |
| title_full_unstemmed | Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery |
| title_short | Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery |
| title_sort | development and evaluation of magnetite loaded alginate beads based nanocomposite for enhanced targeted analgesic drug delivery |
| topic | magnetic nanoparticle sodium alginate aceclofenac vibrating sample magnetometry targeted therapeutic |
| url | https://www.mdpi.com/2312-7481/11/2/14 |
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