Electron Paramagnetic Resonance Study of Thermally Treated Bismuth Subgallate
Complex of bismuth, an anti-inflammatory drug, was studied by EPR spectroscopy. The aim of this study was to determine concentrations and properties of free radicals formed during thermal sterilization of bismuth subgallate according to pharmacopoeia norms to optimize its sterilization process. Diff...
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Wiley
2014-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2014/547032 |
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| author | Paweł Ramos Barbara Pilawa |
| author_facet | Paweł Ramos Barbara Pilawa |
| author_sort | Paweł Ramos |
| collection | DOAJ |
| description | Complex of bismuth, an anti-inflammatory drug, was studied by EPR spectroscopy. The aim of this study was to determine concentrations and properties of free radicals formed during thermal sterilization of bismuth subgallate according to pharmacopoeia norms to optimize its sterilization process. Different temperatures (160°C, 170°C, and 180°C) and times (120 minutes, 60 minutes, and 30 minutes) of sterilization were used. Interactions of bismuth subgallate with DPPH, the model free radical reference, were checked. g-Factors, amplitudes (A), integral intensities (I), and linewidths (ΔBpp) were obtained. Integral intensities were obtained by double integration of the first-derivative EPR lines. The influence of microwave power in the range of 2.2–70 mW on shape and parameters of the EPR spectra was examined. Thermal sterilization produced free radicals in bismuth subgallate in all tested cases. Strong interactions with free radicals were pointed out for all the analysed samples containing bismuth independent of sterilization conditions. Optimal conditions of thermal sterilization for bismuth subgallate with the lowest free radical formation are temperature 170°C and time of heating 60 minutes. Strong dipolar interactions exist in thermally sterilized bismuth subgallate. EPR spectroscopy is a useful method of examination of thermal sterilization conditions. |
| format | Article |
| id | doaj-art-08d17c5884614aefa30e2e7af301b746 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-08d17c5884614aefa30e2e7af301b7462025-02-03T06:01:04ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2014-01-01201410.1155/2014/547032547032Electron Paramagnetic Resonance Study of Thermally Treated Bismuth SubgallatePaweł Ramos0Barbara Pilawa1School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Biophysics, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, PolandSchool of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Biophysics, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, PolandComplex of bismuth, an anti-inflammatory drug, was studied by EPR spectroscopy. The aim of this study was to determine concentrations and properties of free radicals formed during thermal sterilization of bismuth subgallate according to pharmacopoeia norms to optimize its sterilization process. Different temperatures (160°C, 170°C, and 180°C) and times (120 minutes, 60 minutes, and 30 minutes) of sterilization were used. Interactions of bismuth subgallate with DPPH, the model free radical reference, were checked. g-Factors, amplitudes (A), integral intensities (I), and linewidths (ΔBpp) were obtained. Integral intensities were obtained by double integration of the first-derivative EPR lines. The influence of microwave power in the range of 2.2–70 mW on shape and parameters of the EPR spectra was examined. Thermal sterilization produced free radicals in bismuth subgallate in all tested cases. Strong interactions with free radicals were pointed out for all the analysed samples containing bismuth independent of sterilization conditions. Optimal conditions of thermal sterilization for bismuth subgallate with the lowest free radical formation are temperature 170°C and time of heating 60 minutes. Strong dipolar interactions exist in thermally sterilized bismuth subgallate. EPR spectroscopy is a useful method of examination of thermal sterilization conditions.http://dx.doi.org/10.1155/2014/547032 |
| spellingShingle | Paweł Ramos Barbara Pilawa Electron Paramagnetic Resonance Study of Thermally Treated Bismuth Subgallate Bioinorganic Chemistry and Applications |
| title | Electron Paramagnetic Resonance Study of Thermally Treated Bismuth Subgallate |
| title_full | Electron Paramagnetic Resonance Study of Thermally Treated Bismuth Subgallate |
| title_fullStr | Electron Paramagnetic Resonance Study of Thermally Treated Bismuth Subgallate |
| title_full_unstemmed | Electron Paramagnetic Resonance Study of Thermally Treated Bismuth Subgallate |
| title_short | Electron Paramagnetic Resonance Study of Thermally Treated Bismuth Subgallate |
| title_sort | electron paramagnetic resonance study of thermally treated bismuth subgallate |
| url | http://dx.doi.org/10.1155/2014/547032 |
| work_keys_str_mv | AT pawełramos electronparamagneticresonancestudyofthermallytreatedbismuthsubgallate AT barbarapilawa electronparamagneticresonancestudyofthermallytreatedbismuthsubgallate |