Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis
Super activated platelet lysate (sPL) is a derivative of platelet-rich plasma (PRP) that contains high levels of several growth factors. In this study, we synthesized a temperature-sensitive hydrogel that contained temperature-sensitive Poly(DL-lactide-glycolide-glycolide acid) (PLGA), SrCl2, and HA...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/7951616 |
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| _version_ | 1832546175199215616 |
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| author | Zhipeng Huang Zhe Zhao Jun Lang Wantao Wang Yinsheng Fu Wenbo Wang |
| author_facet | Zhipeng Huang Zhe Zhao Jun Lang Wantao Wang Yinsheng Fu Wenbo Wang |
| author_sort | Zhipeng Huang |
| collection | DOAJ |
| description | Super activated platelet lysate (sPL) is a derivative of platelet-rich plasma (PRP) that contains high levels of several growth factors. In this study, we synthesized a temperature-sensitive hydrogel that contained temperature-sensitive Poly(DL-lactide-glycolide-glycolide acid) (PLGA), SrCl2, and HA, and loaded it with different concentrations of sPL. The hydrogel showed satisfactory encapsulation efficiency and release of the growth factors in a sustained manner, indicating its suitability as a drug carrier. The sPL-loaded hydrogel was inserted into the necrotic femoral head of a rat model and core decompression was applied and resulted in significantly accelerated bone repair and regeneration. Therefore, encapsulation of sPL in a hydrogel scaffolding may be an effective strategy for treating femoral head necrosis. |
| format | Article |
| id | doaj-art-08cd56c95b34421abf8c6974c7294f77 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-08cd56c95b34421abf8c6974c7294f772025-02-03T07:23:31ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/79516167951616Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head NecrosisZhipeng Huang0Zhe Zhao1Jun Lang2Wantao Wang3Yinsheng Fu4Wenbo Wang5The First Affiliated Hospital of Harbin Medical University, 23 You Zheng Street, Harbin 150001, ChinaSouthern University of Science and Technology Hospital, 6019 Liuxian Avenue, Xili, Nanshan District, Shenzhen 518000, ChinaThe First Affiliated Hospital of Harbin Medical University, 23 You Zheng Street, Harbin 150001, ChinaThe First Affiliated Hospital of Harbin Medical University, 23 You Zheng Street, Harbin 150001, ChinaTianqing Stem Cell Co., Ltd., Jubao Second Road, Science and Technology Innovation City, Songbei District, Harbin 150000, ChinaThe First Affiliated Hospital of Harbin Medical University, 23 You Zheng Street, Harbin 150001, ChinaSuper activated platelet lysate (sPL) is a derivative of platelet-rich plasma (PRP) that contains high levels of several growth factors. In this study, we synthesized a temperature-sensitive hydrogel that contained temperature-sensitive Poly(DL-lactide-glycolide-glycolide acid) (PLGA), SrCl2, and HA, and loaded it with different concentrations of sPL. The hydrogel showed satisfactory encapsulation efficiency and release of the growth factors in a sustained manner, indicating its suitability as a drug carrier. The sPL-loaded hydrogel was inserted into the necrotic femoral head of a rat model and core decompression was applied and resulted in significantly accelerated bone repair and regeneration. Therefore, encapsulation of sPL in a hydrogel scaffolding may be an effective strategy for treating femoral head necrosis.http://dx.doi.org/10.1155/2021/7951616 |
| spellingShingle | Zhipeng Huang Zhe Zhao Jun Lang Wantao Wang Yinsheng Fu Wenbo Wang Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis Stem Cells International |
| title | Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis |
| title_full | Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis |
| title_fullStr | Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis |
| title_full_unstemmed | Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis |
| title_short | Therapeutic Study of Thermosensitive Hydrogel Loaded with Super-Activated Platelet Lysate Combined with Core Decompression Technology for the Treatment of Femoral Head Necrosis |
| title_sort | therapeutic study of thermosensitive hydrogel loaded with super activated platelet lysate combined with core decompression technology for the treatment of femoral head necrosis |
| url | http://dx.doi.org/10.1155/2021/7951616 |
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