Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry
Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer’s disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. In addition to the direct volumetric and thickness measurement based on high-resolution magn...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/3954101 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567284712865792 |
|---|---|
| author | Xiaojing Long Chunxiang Jiang Lijuan Zhang |
| author_facet | Xiaojing Long Chunxiang Jiang Lijuan Zhang |
| author_sort | Xiaojing Long |
| collection | DOAJ |
| description | Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer’s disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. In addition to the direct volumetric and thickness measurement based on high-resolution magnetic resonance imaging (MRI), hemispheric asymmetry could be a potential index to detect morphological variations in MCI patients with a high risk of conversion to AD. The present study collected a set of longitudinal MRI data from 53 MCI converters and nonconverters and investigated the asymmetry differences between groups. Asymmetry variation was observed in the medial temporal lobe, especially in the entorhinal cortex, between converters and nonconverters 3 years before the former developed AD. The proposed asymmetry analysis was observed to be sensitive to detect morphological changes between groups as compared to the methods of voxel-based morphometry (VBM) and thickness measurement. Hemispheric asymmetry in specific brain regions as a neuroimaging biomarker can provide helpful information for prediction of MCI conversion. |
| format | Article |
| id | doaj-art-08cb5281690741f8b4276ed33fb2a5f5 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-08cb5281690741f8b4276ed33fb2a5f52025-02-03T01:01:47ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/39541013954101Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric AsymmetryXiaojing Long0Chunxiang Jiang1Lijuan Zhang2Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, ChinaPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, ChinaPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, ChinaIdentifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer’s disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. In addition to the direct volumetric and thickness measurement based on high-resolution magnetic resonance imaging (MRI), hemispheric asymmetry could be a potential index to detect morphological variations in MCI patients with a high risk of conversion to AD. The present study collected a set of longitudinal MRI data from 53 MCI converters and nonconverters and investigated the asymmetry differences between groups. Asymmetry variation was observed in the medial temporal lobe, especially in the entorhinal cortex, between converters and nonconverters 3 years before the former developed AD. The proposed asymmetry analysis was observed to be sensitive to detect morphological changes between groups as compared to the methods of voxel-based morphometry (VBM) and thickness measurement. Hemispheric asymmetry in specific brain regions as a neuroimaging biomarker can provide helpful information for prediction of MCI conversion.http://dx.doi.org/10.1155/2018/3954101 |
| spellingShingle | Xiaojing Long Chunxiang Jiang Lijuan Zhang Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry Behavioural Neurology |
| title | Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry |
| title_full | Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry |
| title_fullStr | Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry |
| title_full_unstemmed | Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry |
| title_short | Morphological Biomarker Differentiating MCI Converters from Nonconverters: Longitudinal Evidence Based on Hemispheric Asymmetry |
| title_sort | morphological biomarker differentiating mci converters from nonconverters longitudinal evidence based on hemispheric asymmetry |
| url | http://dx.doi.org/10.1155/2018/3954101 |
| work_keys_str_mv | AT xiaojinglong morphologicalbiomarkerdifferentiatingmciconvertersfromnonconverterslongitudinalevidencebasedonhemisphericasymmetry AT chunxiangjiang morphologicalbiomarkerdifferentiatingmciconvertersfromnonconverterslongitudinalevidencebasedonhemisphericasymmetry AT lijuanzhang morphologicalbiomarkerdifferentiatingmciconvertersfromnonconverterslongitudinalevidencebasedonhemisphericasymmetry |