Development and validation of a high-performance liquid chromatography with tandem mass spectrometry method for quantification of tofacitinib in human plasma

Development and validation of a high-performance liquid chromatography with tandem mass spectrometry method for quantification of tofacitinib in human plasma

Introduction. The use of tofacitinib as a pharmacological treatment for rheumatoid arthritis remains relevant in the light of the predicted increase in prevalence of the disease. At the same time, due to the withdrawal of several foreign pharmaceutical companies from the Russian pharmaceutical marke...

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Bibliographic Details
Main Authors: E. S. Vetrova, P. K. Karnakova, N. S. Bagaeva, K. K. Karnakova, M. O. Popova, A. A. Popova, O. A. Archakova, T. N. Komarov, I. E. Shohin
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2024-06-01
Series:Разработка и регистрация лекарственных средств
Subjects:
tofacitinib
validation
lc-ms/ms
bioequivalence
pharmacokinetics
bioanalytical study
Online Access:https://www.pharmjournal.ru/jour/article/view/1838
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