Structures and mechanisms of the RNA m<sup>6</sup>A writer
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA me...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-09-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024152 |
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| _version_ | 1832590304340869120 |
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| author | Deng Ting Ma Jinbiao |
| author_facet | Deng Ting Ma Jinbiao |
| author_sort | Deng Ting |
| collection | DOAJ |
| description | N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA metabolism. The m<sup>6</sup>A writer for mRNAs and long non-coding RNAs consists of the catalytic subunit m<sup>6</sup>A-METTL complex (MTC) (including METTL3/METTL14) and the regulatory subunit m<sup>6</sup>A-METTL-associated complex (MACOM) (including HAKAI, WTAP, VIRMA, ZC3H13, and RBM15/15B). In this review, we focus on recent advances in our understanding of the structural and functional properties of m<sup>6</sup>A writers and the possible mechanism by which they recognize RNA substrates and perform selective m<sup>6</sup>A modifications. |
| format | Article |
| id | doaj-art-08aeab59269f447c9fa8d85efc7d59d1 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-08aeab59269f447c9fa8d85efc7d59d12025-01-24T00:56:46ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-09-0157597210.3724/abbs.202415220d259ccStructures and mechanisms of the RNA m<sup>6</sup>A writerDeng Ting0Ma Jinbiao1[][]N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA metabolism. The m<sup>6</sup>A writer for mRNAs and long non-coding RNAs consists of the catalytic subunit m<sup>6</sup>A-METTL complex (MTC) (including METTL3/METTL14) and the regulatory subunit m<sup>6</sup>A-METTL-associated complex (MACOM) (including HAKAI, WTAP, VIRMA, ZC3H13, and RBM15/15B). In this review, we focus on recent advances in our understanding of the structural and functional properties of m<sup>6</sup>A writers and the possible mechanism by which they recognize RNA substrates and perform selective m<sup>6</sup>A modifications.https://www.sciengine.com/doi/10.3724/abbs.2024152 |
| spellingShingle | Deng Ting Ma Jinbiao Structures and mechanisms of the RNA m<sup>6</sup>A writer Acta Biochimica et Biophysica Sinica |
| title | Structures and mechanisms of the RNA m<sup>6</sup>A writer |
| title_full | Structures and mechanisms of the RNA m<sup>6</sup>A writer |
| title_fullStr | Structures and mechanisms of the RNA m<sup>6</sup>A writer |
| title_full_unstemmed | Structures and mechanisms of the RNA m<sup>6</sup>A writer |
| title_short | Structures and mechanisms of the RNA m<sup>6</sup>A writer |
| title_sort | structures and mechanisms of the rna m sup 6 sup a writer |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024152 |
| work_keys_str_mv | AT dengting structuresandmechanismsofthernamsup6supawriter AT majinbiao structuresandmechanismsofthernamsup6supawriter |