Structures and mechanisms of the RNA m<sup>6</sup>A writer
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA me...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
China Science Publishing & Media Ltd.
2024-09-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024152 |
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| Summary: | N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA metabolism. The m<sup>6</sup>A writer for mRNAs and long non-coding RNAs consists of the catalytic subunit m<sup>6</sup>A-METTL complex (MTC) (including METTL3/METTL14) and the regulatory subunit m<sup>6</sup>A-METTL-associated complex (MACOM) (including HAKAI, WTAP, VIRMA, ZC3H13, and RBM15/15B). In this review, we focus on recent advances in our understanding of the structural and functional properties of m<sup>6</sup>A writers and the possible mechanism by which they recognize RNA substrates and perform selective m<sup>6</sup>A modifications. |
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| ISSN: | 1672-9145 |