Does the intensity of dissociation predict antidepressant effects 24 hours after infusion of racemic ketamine or esketamine in treatment-resistant depression? A secondary analysis from a randomized controlled trial

Abstract Objective Ketamine and esketamine have both shown significant antidepressant effects in treatment-resistant depression (TRD) and conflicting evidence suggests that dissociation induced by these drugs could be a clinical predictor of esketamine/ketamine's efficacy. Methods This study...

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Main Authors:	Mariana V. F. Echegaray, Rodrigo P. Mello, Guilherme M. Magnavita, Gustavo C. Leal, Fernanda S. Correia-Melo, Ana Paula Jesus-Nunes, Flávia Vieira, Igor D. Bandeira, Ana Teresa Caliman-Fontes, Manuela Telles, Lívia N. F. Guerreiro-Costa, Roberta Ferrari Marback, Breno Souza-Marques, Daniel H. Lins-Silva, Cassio Santos-Lima, Taiane de Azevedo Cardoso, Flávio Kapczinski, Acioly L. T. Lacerda, Lucas C. Quarantini
Format:	Article
Language:	English
Published:	Associação de Psiquiatria do Rio Grande do Sul 2025-05-01
Series:	Trends in Psychiatry and Psychotherapy
Subjects:	Ketamine esketamine treatment-resistant depression major depressive disorder dissociation
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892025000100505&lng=en&tlng=en
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Does the intensity of dissociation predict antidepressant effects 24 hours after infusion of racemic ketamine or esketamine in treatment-resistant depression? A secondary analysis from a randomized controlled trial

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