Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
Purpose. We performed a systematic review and meta-analysis to evaluate the association between cataract surgery and the development and progression of AMD. Methods. This meta-analysis was registered at PROSPERO (CRD42017077962). We conducted a systematic literature search in August 2020 in Embase a...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/6780901 |
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| _version_ | 1832545622172893184 |
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| author | Lihong Yang Hongxun Li Xinheng Zhao Ye Pan |
| author_facet | Lihong Yang Hongxun Li Xinheng Zhao Ye Pan |
| author_sort | Lihong Yang |
| collection | DOAJ |
| description | Purpose. We performed a systematic review and meta-analysis to evaluate the association between cataract surgery and the development and progression of AMD. Methods. This meta-analysis was registered at PROSPERO (CRD42017077962). We conducted a systematic literature search in August 2020 in Embase and PubMed and included cohort studies, case-control studies, or randomized controlled trials (RCTs) if they examined the association between cataract surgery and AMD. Odds ratio (OR) was used as a measure of the association with a random effect model. The analysis was further stratified by factors that could affect the outcomes. Results. 15 studies were included in this study. In the overall analysis, cataract surgery was significantly associated with the incidence of late AMD (OR, 1.80; 95% CI, 1.26–2.56; P = 0.001), particularly geographic atrophy (OR, 3.20; 95% CI, 1.90–5.39; P ≤ 0.001). No significant associations were observed between cataract surgery and the incidence of early AMD. Subgroup analysis showed that the OR for incidence of early and late AMD was significantly higher for cataract surgery performed more than 5 years compared with less than 5 years. We also found an increased risk of progression of AMD after cataract surgery performed more than 5 years (OR, 1.97; 95% CI, 1.29–3.01; P = 0.002). Conclusions. Our results suggest that cataract surgery may be associated with an increased risk of late AMD development and AMD progression. In addition, increasing the follow-up time since cataract surgery may further increase the risk for the development and progression of AMD. In the future, prospective multicenter studies with well-designed RCTs are required to confirm our findings. |
| format | Article |
| id | doaj-art-087f6baf9b8c4992a5005585395f5b0c |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-087f6baf9b8c4992a5005585395f5b0c2025-02-03T07:25:03ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/6780901Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-AnalysisLihong Yang0Hongxun Li1Xinheng Zhao2Ye Pan3Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Key Lab of Ophthalmology and Visual ScienceTianjin Key Lab of Ophthalmology and Visual ScienceTianjin Key Lab of Ophthalmology and Visual SciencePurpose. We performed a systematic review and meta-analysis to evaluate the association between cataract surgery and the development and progression of AMD. Methods. This meta-analysis was registered at PROSPERO (CRD42017077962). We conducted a systematic literature search in August 2020 in Embase and PubMed and included cohort studies, case-control studies, or randomized controlled trials (RCTs) if they examined the association between cataract surgery and AMD. Odds ratio (OR) was used as a measure of the association with a random effect model. The analysis was further stratified by factors that could affect the outcomes. Results. 15 studies were included in this study. In the overall analysis, cataract surgery was significantly associated with the incidence of late AMD (OR, 1.80; 95% CI, 1.26–2.56; P = 0.001), particularly geographic atrophy (OR, 3.20; 95% CI, 1.90–5.39; P ≤ 0.001). No significant associations were observed between cataract surgery and the incidence of early AMD. Subgroup analysis showed that the OR for incidence of early and late AMD was significantly higher for cataract surgery performed more than 5 years compared with less than 5 years. We also found an increased risk of progression of AMD after cataract surgery performed more than 5 years (OR, 1.97; 95% CI, 1.29–3.01; P = 0.002). Conclusions. Our results suggest that cataract surgery may be associated with an increased risk of late AMD development and AMD progression. In addition, increasing the follow-up time since cataract surgery may further increase the risk for the development and progression of AMD. In the future, prospective multicenter studies with well-designed RCTs are required to confirm our findings.http://dx.doi.org/10.1155/2022/6780901 |
| spellingShingle | Lihong Yang Hongxun Li Xinheng Zhao Ye Pan Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis Journal of Ophthalmology |
| title | Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_full | Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_fullStr | Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_short | Association between Cataract Surgery and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_sort | association between cataract surgery and age related macular degeneration a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2022/6780901 |
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