Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine
Peptide-loaded poly(lactide-co-glycolide) (PLGA) nanocarriers represent a transformative approach to addressing the challenges of peptide-based therapies. These systems offer solutions to peptide instability, enzymatic degradation, and limited bioavailability by providing controlled release, targete...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/1/127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587688035745792 |
|---|---|
| author | Hossein Omidian Renae L. Wilson Ana M. Castejon |
| author_facet | Hossein Omidian Renae L. Wilson Ana M. Castejon |
| author_sort | Hossein Omidian |
| collection | DOAJ |
| description | Peptide-loaded poly(lactide-co-glycolide) (PLGA) nanocarriers represent a transformative approach to addressing the challenges of peptide-based therapies. These systems offer solutions to peptide instability, enzymatic degradation, and limited bioavailability by providing controlled release, targeted delivery, and improved stability. The versatility of PLGA nanocarriers extends across therapeutic domains, including cancer therapy, neurodegenerative diseases, vaccine development, and regenerative medicine. Innovations in polymer chemistry, surface functionalization, and advanced manufacturing techniques, such as microfluidics and electrospraying, have further enhanced the efficacy and scalability of these systems. This review highlights the key physicochemical properties, preparation strategies, and proven benefits of peptide-loaded PLGA systems, emphasizing their role in sustained drug release, immune activation, and tissue regeneration. Despite remarkable progress, challenges such as production scalability, cost, and regulatory hurdles remain. |
| format | Article |
| id | doaj-art-086f357ee1dd4080ac776a231f2fcb10 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-086f357ee1dd4080ac776a231f2fcb102025-01-24T13:45:29ZengMDPI AGPharmaceuticals1424-82472025-01-0118112710.3390/ph18010127Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative MedicineHossein Omidian0Renae L. Wilson1Ana M. Castejon2Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USABarry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USABarry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USAPeptide-loaded poly(lactide-co-glycolide) (PLGA) nanocarriers represent a transformative approach to addressing the challenges of peptide-based therapies. These systems offer solutions to peptide instability, enzymatic degradation, and limited bioavailability by providing controlled release, targeted delivery, and improved stability. The versatility of PLGA nanocarriers extends across therapeutic domains, including cancer therapy, neurodegenerative diseases, vaccine development, and regenerative medicine. Innovations in polymer chemistry, surface functionalization, and advanced manufacturing techniques, such as microfluidics and electrospraying, have further enhanced the efficacy and scalability of these systems. This review highlights the key physicochemical properties, preparation strategies, and proven benefits of peptide-loaded PLGA systems, emphasizing their role in sustained drug release, immune activation, and tissue regeneration. Despite remarkable progress, challenges such as production scalability, cost, and regulatory hurdles remain.https://www.mdpi.com/1424-8247/18/1/127peptide therapeuticsPLGA nanocarrierscontrolled drug releaseregenerative medicinetargeted drug delivery |
| spellingShingle | Hossein Omidian Renae L. Wilson Ana M. Castejon Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine Pharmaceuticals peptide therapeutics PLGA nanocarriers controlled drug release regenerative medicine targeted drug delivery |
| title | Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine |
| title_full | Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine |
| title_fullStr | Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine |
| title_full_unstemmed | Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine |
| title_short | Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine |
| title_sort | recent advances in peptide loaded plga nanocarriers for drug delivery and regenerative medicine |
| topic | peptide therapeutics PLGA nanocarriers controlled drug release regenerative medicine targeted drug delivery |
| url | https://www.mdpi.com/1424-8247/18/1/127 |
| work_keys_str_mv | AT hosseinomidian recentadvancesinpeptideloadedplgananocarriersfordrugdeliveryandregenerativemedicine AT renaelwilson recentadvancesinpeptideloadedplgananocarriersfordrugdeliveryandregenerativemedicine AT anamcastejon recentadvancesinpeptideloadedplgananocarriersfordrugdeliveryandregenerativemedicine |