The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives
A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-<i>d</i>]pyrimidin-7(6<i>H</i>)-one structure was synthesized through efficient Thorpe–Ziegler and cyclization reactions. The thiazolo[4,...
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MDPI AG
2025-01-01
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| author | Shuanghui Hua Jimin Moon Taeho Lee |
| author_facet | Shuanghui Hua Jimin Moon Taeho Lee |
| author_sort | Shuanghui Hua |
| collection | DOAJ |
| description | A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-<i>d</i>]pyrimidin-7(6<i>H</i>)-one structure was synthesized through efficient Thorpe–Ziegler and cyclization reactions. The thiazolo[4,5-<i>d</i>]pyrimidin-7(6<i>H</i>)-one derivative library with a diversity of three had a total of four synthesis steps and 57 compounds. In addition, the yield per synthesis step was 65–97%, which was very high. The developed synthesis method and compounds will be used to find compounds with biological activity through the thiazole derivative structure–activity relationship. |
| format | Article |
| id | doaj-art-085a48e1649f46b1a83321f48acdaf28 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-085a48e1649f46b1a83321f48acdaf282025-01-24T13:44:01ZengMDPI AGMolecules1420-30492025-01-0130243010.3390/molecules30020430The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone DerivativesShuanghui Hua0Jimin Moon1Taeho Lee2Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 702-701, Republic of KoreaResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 702-701, Republic of KoreaResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 702-701, Republic of KoreaA thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-<i>d</i>]pyrimidin-7(6<i>H</i>)-one structure was synthesized through efficient Thorpe–Ziegler and cyclization reactions. The thiazolo[4,5-<i>d</i>]pyrimidin-7(6<i>H</i>)-one derivative library with a diversity of three had a total of four synthesis steps and 57 compounds. In addition, the yield per synthesis step was 65–97%, which was very high. The developed synthesis method and compounds will be used to find compounds with biological activity through the thiazole derivative structure–activity relationship.https://www.mdpi.com/1420-3049/30/2/430thiazolesolid-phase synthesischemical library |
| spellingShingle | Shuanghui Hua Jimin Moon Taeho Lee The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives Molecules thiazole solid-phase synthesis chemical library |
| title | The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives |
| title_full | The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives |
| title_fullStr | The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives |
| title_full_unstemmed | The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives |
| title_short | The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives |
| title_sort | facile solid phase synthesis of thiazolo pyrimidinone derivatives |
| topic | thiazole solid-phase synthesis chemical library |
| url | https://www.mdpi.com/1420-3049/30/2/430 |
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