Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors
Positron emission tomography (PET) is an imaging technology that can detect and characterize tumors based on their molecular and biochemical properties, such as altered glucose, nucleoside, or amino acid metabolism. PET plays a significant role in the diagnosis, prognostication, and treatment of var...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2014.00015 |
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| author | Csaba Juhász Shalini Dwivedi David O. Kamson Sharon K. Michelhaugh Sandeep Mittal |
| author_facet | Csaba Juhász Shalini Dwivedi David O. Kamson Sharon K. Michelhaugh Sandeep Mittal |
| author_sort | Csaba Juhász |
| collection | DOAJ |
| description | Positron emission tomography (PET) is an imaging technology that can detect and characterize tumors based on their molecular and biochemical properties, such as altered glucose, nucleoside, or amino acid metabolism. PET plays a significant role in the diagnosis, prognostication, and treatment of various cancers, including brain tumors. In this article, we compare uptake mechanisms and the clinical performance of the amino acid PET radiotracers (L-[methyl- 11 C]methionine [MET], 18 F-fluoroethyl-tyrosine [FET], 18 F-fluoro-L- dihydroxy-phenylalanine [FDOPA], and 11 C-alpha-methyl-L-tryptophan [AMT]) most commonly used for brain tumor imaging. First, we discuss and compare the mechanisms of tumoral transport and accumulation, the basis of differential performance of these radioligands in clinical studies. Then we summarize studies that provided direct comparisons among these amino acid tracers and to clinically used 2-deoxy-2[ 18 F]fluoro-D-glucose [FDG] PET imaging. We also discuss how tracer kinetic analysis can enhance the clinical information obtained from amino acid PET images. We discuss both similarities and differences in potential clinical value for each radioligand. This comparative review can guide which radiotracer to favor in future clinical trials aimed at defining the role of these molecular imaging modalities in the clinical management of brain tumor patients. |
| format | Article |
| id | doaj-art-08544b85741945aea790a3cca061ff15 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-08544b85741945aea790a3cca061ff152025-02-03T10:07:39ZengSAGE PublishingMolecular Imaging1536-01212014-08-011310.2310/7290.2014.0001510.2310_7290.2014.00015Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain TumorsCsaba JuhászShalini DwivediDavid O. KamsonSharon K. MichelhaughSandeep MittalPositron emission tomography (PET) is an imaging technology that can detect and characterize tumors based on their molecular and biochemical properties, such as altered glucose, nucleoside, or amino acid metabolism. PET plays a significant role in the diagnosis, prognostication, and treatment of various cancers, including brain tumors. In this article, we compare uptake mechanisms and the clinical performance of the amino acid PET radiotracers (L-[methyl- 11 C]methionine [MET], 18 F-fluoroethyl-tyrosine [FET], 18 F-fluoro-L- dihydroxy-phenylalanine [FDOPA], and 11 C-alpha-methyl-L-tryptophan [AMT]) most commonly used for brain tumor imaging. First, we discuss and compare the mechanisms of tumoral transport and accumulation, the basis of differential performance of these radioligands in clinical studies. Then we summarize studies that provided direct comparisons among these amino acid tracers and to clinically used 2-deoxy-2[ 18 F]fluoro-D-glucose [FDG] PET imaging. We also discuss how tracer kinetic analysis can enhance the clinical information obtained from amino acid PET images. We discuss both similarities and differences in potential clinical value for each radioligand. This comparative review can guide which radiotracer to favor in future clinical trials aimed at defining the role of these molecular imaging modalities in the clinical management of brain tumor patients.https://doi.org/10.2310/7290.2014.00015 |
| spellingShingle | Csaba Juhász Shalini Dwivedi David O. Kamson Sharon K. Michelhaugh Sandeep Mittal Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors Molecular Imaging |
| title | Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors |
| title_full | Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors |
| title_fullStr | Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors |
| title_full_unstemmed | Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors |
| title_short | Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors |
| title_sort | comparison of amino acid positron emission tomographic radiotracers for molecular imaging of primary and metastatic brain tumors |
| url | https://doi.org/10.2310/7290.2014.00015 |
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