Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent
Irisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible treatment for some metabolic diseases such as o...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2019/6561726 |
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| _version_ | 1832560921149440000 |
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| author | George-Emmanuel Maalouf Diala El Khoury |
| author_facet | George-Emmanuel Maalouf Diala El Khoury |
| author_sort | George-Emmanuel Maalouf |
| collection | DOAJ |
| description | Irisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible treatment for some metabolic diseases such as obesity, insulin resistance, and inflammation. Obesity has been linked to a higher incidence of some cancers. Furthermore, some studies have shown irisin to have direct positive effects on different types of cancers. Although it is hard to relay conclusions from in vitro to in vivo studies, the majority of the available data favor irisin as a potential substance for cancer regression through reducing proinflammatory markers linked to obesity. However, some controversies remain on the exact benefits of irisin on cancer with some studies showing no or even a negative effect of irisin on cancer. This review summarizes these 2 differing viewpoints and synthesizes them to form a clearer picture of exercise-induced irisin’s effects on cancer. |
| format | Article |
| id | doaj-art-0851796113594907ba47323b2f17382b |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-0851796113594907ba47323b2f17382b2025-02-03T01:26:19ZengWileyJournal of Obesity2090-07082090-07162019-01-01201910.1155/2019/65617266561726Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer AgentGeorge-Emmanuel Maalouf0Diala El Khoury1Department of Sciences, Notre Dame University-Louaize, P.O. Box 72, Zouk Mikael, LebanonDepartment of Sciences, Notre Dame University-Louaize, P.O. Box 72, Zouk Mikael, LebanonIrisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible treatment for some metabolic diseases such as obesity, insulin resistance, and inflammation. Obesity has been linked to a higher incidence of some cancers. Furthermore, some studies have shown irisin to have direct positive effects on different types of cancers. Although it is hard to relay conclusions from in vitro to in vivo studies, the majority of the available data favor irisin as a potential substance for cancer regression through reducing proinflammatory markers linked to obesity. However, some controversies remain on the exact benefits of irisin on cancer with some studies showing no or even a negative effect of irisin on cancer. This review summarizes these 2 differing viewpoints and synthesizes them to form a clearer picture of exercise-induced irisin’s effects on cancer.http://dx.doi.org/10.1155/2019/6561726 |
| spellingShingle | George-Emmanuel Maalouf Diala El Khoury Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent Journal of Obesity |
| title | Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent |
| title_full | Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent |
| title_fullStr | Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent |
| title_full_unstemmed | Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent |
| title_short | Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent |
| title_sort | exercise induced irisin the fat browning myokine as a potential anticancer agent |
| url | http://dx.doi.org/10.1155/2019/6561726 |
| work_keys_str_mv | AT georgeemmanuelmaalouf exerciseinducedirisinthefatbrowningmyokineasapotentialanticanceragent AT dialaelkhoury exerciseinducedirisinthefatbrowningmyokineasapotentialanticanceragent |