Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis
Long-term intake of high-fat diet (HFD) leads to systemic hypo-inflammation, which is involved in the pathogenesis of many liver diseases. The aim of this study was to evaluate the interventional effect of inulin addition on HFD-induced non-alcoholic fatty liver disease (NAFLD). Here, we assessed li...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2025-02-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250040 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850037715046760448 |
|---|---|
| author | Wei Song Jinhong Hu Lina Zhu Bing Chen Lingling Li Xiaole Cui Ting Zhang Yaxing Miao Kaixin Su Changchun Liu Yane Luo Tianli Yue |
| author_facet | Wei Song Jinhong Hu Lina Zhu Bing Chen Lingling Li Xiaole Cui Ting Zhang Yaxing Miao Kaixin Su Changchun Liu Yane Luo Tianli Yue |
| author_sort | Wei Song |
| collection | DOAJ |
| description | Long-term intake of high-fat diet (HFD) leads to systemic hypo-inflammation, which is involved in the pathogenesis of many liver diseases. The aim of this study was to evaluate the interventional effect of inulin addition on HFD-induced non-alcoholic fatty liver disease (NAFLD). Here, we assessed liver inflammation and lipid metabolism by enzyme linked immunosorbent assay (ELISA) kits and real-time quantitative polymerase chain reaction (qPCR), and explored its relationship with intestinal flora and metabolites by 16S rDNA gene sequencing and untargeted metabolomics. In addition, we determined the effect of the inositol-requiring enzyme-1α-X-box binding protein 1 (IRE1α-XBP1) pathway on liver macrophage polarization by flow cytometry. In conclusion, our study has demonstrated that inulin ameliorates high levels of bile acids and colonic immune disorders induced by HFD, and improves hepatic macrophage polarization and hepatic lipid metabolism via the intestine-hepatic axis, thus providing a mechanistic basis for therapeutic approaches to modulate bile acids to improve colonic inflammation and NAFLD. |
| format | Article |
| id | doaj-art-084bcd4e7e764c27addb85be967ec060 |
| institution | DOAJ |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-084bcd4e7e764c27addb85be967ec0602025-08-20T02:56:47ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-02-01142925004010.26599/FSHW.2024.9250040Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axisWei Song0Jinhong Hu1Lina Zhu2Bing Chen3Lingling Li4Xiaole Cui5Ting Zhang6Yaxing Miao7Kaixin Su8Changchun Liu9Yane Luo10Tianli Yue11College of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaCollege of Food Science and Technology, Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Research Center of Food Safety Risk Assessment and Control, Northwest University, Xi’an 710069, ChinaLong-term intake of high-fat diet (HFD) leads to systemic hypo-inflammation, which is involved in the pathogenesis of many liver diseases. The aim of this study was to evaluate the interventional effect of inulin addition on HFD-induced non-alcoholic fatty liver disease (NAFLD). Here, we assessed liver inflammation and lipid metabolism by enzyme linked immunosorbent assay (ELISA) kits and real-time quantitative polymerase chain reaction (qPCR), and explored its relationship with intestinal flora and metabolites by 16S rDNA gene sequencing and untargeted metabolomics. In addition, we determined the effect of the inositol-requiring enzyme-1α-X-box binding protein 1 (IRE1α-XBP1) pathway on liver macrophage polarization by flow cytometry. In conclusion, our study has demonstrated that inulin ameliorates high levels of bile acids and colonic immune disorders induced by HFD, and improves hepatic macrophage polarization and hepatic lipid metabolism via the intestine-hepatic axis, thus providing a mechanistic basis for therapeutic approaches to modulate bile acids to improve colonic inflammation and NAFLD.https://www.sciopen.com/article/10.26599/FSHW.2024.9250040high-fat dietnon-alcoholic fatty liver diseasemacrophage polarizationbile acidire1α-xbp1 pathway |
| spellingShingle | Wei Song Jinhong Hu Lina Zhu Bing Chen Lingling Li Xiaole Cui Ting Zhang Yaxing Miao Kaixin Su Changchun Liu Yane Luo Tianli Yue Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis Food Science and Human Wellness high-fat diet non-alcoholic fatty liver disease macrophage polarization bile acid ire1α-xbp1 pathway |
| title | Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis |
| title_full | Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis |
| title_fullStr | Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis |
| title_full_unstemmed | Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis |
| title_short | Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis |
| title_sort | inulin alleviates hfd induced nafld by hepatic macrophage polarization and lipid metabolism via gut liver axis |
| topic | high-fat diet non-alcoholic fatty liver disease macrophage polarization bile acid ire1α-xbp1 pathway |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250040 |
| work_keys_str_mv | AT weisong inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT jinhonghu inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT linazhu inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT bingchen inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT linglingli inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT xiaolecui inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT tingzhang inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT yaxingmiao inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT kaixinsu inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT changchunliu inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT yaneluo inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis AT tianliyue inulinalleviateshfdinducednafldbyhepaticmacrophagepolarizationandlipidmetabolismviagutliveraxis |