IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carc...

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Bibliographic Details
Main Authors:	Zhi-Yong Wang, Jun-Ai Zhang, Xian-Jin Wu, Yan-Fang Liang, Yuan-Bin Lu, Yu-Chi Gao, You-Chao Dai, Shi-Yan Yu, Yan Jia, Xiao-Xia Fu, Xiaoquan Rao, Jun-Fa Xu, Jixin Zhong
Format:	Article
Language:	English
Published:	Wiley 2016-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2016/8026494
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