Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series
Early-stage laryngeal cancer (T1-T2) is commonly treated with organ-preserving techniques such as transoral laser microsurgery (TOLMS) or radiation therapy (RT), both providing comparable oncological outcomes but differing in functional results. Local recurrence occurs in approximately 10% of cases,...
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2024-12-01
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| Series: | Current Oncology |
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| author | Erika Crosetti Andrea Borello Andy Bertolin Izabela Costa Santos Marco Fantini Giulia Arrigoni Ilaria Bertotto Andrea Elio Sprio Fernando Luiz Dias Giuseppe Rizzotto Giovanni Succo |
| author_facet | Erika Crosetti Andrea Borello Andy Bertolin Izabela Costa Santos Marco Fantini Giulia Arrigoni Ilaria Bertotto Andrea Elio Sprio Fernando Luiz Dias Giuseppe Rizzotto Giovanni Succo |
| author_sort | Erika Crosetti |
| collection | DOAJ |
| description | Early-stage laryngeal cancer (T1-T2) is commonly treated with organ-preserving techniques such as transoral laser microsurgery (TOLMS) or radiation therapy (RT), both providing comparable oncological outcomes but differing in functional results. Local recurrence occurs in approximately 10% of cases, making salvage surgery a crucial therapeutic option. This multi-institutional study investigates the efficacy of open partial horizontal laryngectomy (OPHL) as a salvage treatment, following recurrent laryngeal squamous-cell carcinoma (LSCC) after failed TOLMS. This analysis includes 66 patients who underwent OPHL between 1995 and 2017, reporting favorable oncological outcomes with overall survival (OS) of 87.4%, disease-specific survival (DSS) of 93.4%, and disease-free survival (DFS) of 85.5%. A recurrence rate of 10.6% was observed post-salvage OPHL, with vascular invasion and advanced pathological staging identified as significant predictors of recurrence. OPHL emerged as an effective organ-preserving alternative to total laryngectomy (TL) in select patients, especially those with limited tumor spread and preserved laryngeal function. The study highlights the importance of careful patient selection and thorough preoperative assessment to improve outcomes, positioning OPHL as a key option in treating recurrent laryngeal cancer and offering oncological control while preserving laryngeal functions. |
| format | Article |
| id | doaj-art-0830155093444cb28b941d14e7ff9c3d |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-0830155093444cb28b941d14e7ff9c3d2025-01-24T13:28:21ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-013211210.3390/curroncol32010012Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional SeriesErika Crosetti0Andrea Borello1Andy Bertolin2Izabela Costa Santos3Marco Fantini4Giulia Arrigoni5Ilaria Bertotto6Andrea Elio Sprio7Fernando Luiz Dias8Giuseppe Rizzotto9Giovanni Succo10Otorhinolaryngology Unit, San Giovanni Bosco Hospital, 10154 Torino, ItalyOtorhinolaryngology Unit, Michele and Pietro Ferrero Hospital, 12060 Verduno, ItalyOtorhinolaryngology Unit, Vittorio Veneto Hospital, AULSS2 Treviso, 31029 Vittorio Veneto, ItalyBrazilian National Cancer Institute, Rio de Janeiro 20230-130, RJ, BrazilOtorhinolaryngology Unit, San Giovanni Bosco Hospital, 10154 Torino, ItalyOtorhinolaryngology Unit, San Giovanni Bosco Hospital, 10154 Torino, ItalyRadiology Service, Candiolo Cancer Institute, FPO IRCCS, Candiolo, 10060 Turin, ItalyDepartment of Research, ASOMI College of Sciences, 2080 Marsa, MaltaBrazilian National Cancer Institute, Rio de Janeiro 20230-130, RJ, BrazilOtorhinolaryngology Unit, Vittorio Veneto Hospital, AULSS2 Treviso, 31029 Vittorio Veneto, ItalyOtorhinolaryngology Unit, San Giovanni Bosco Hospital, 10154 Torino, ItalyEarly-stage laryngeal cancer (T1-T2) is commonly treated with organ-preserving techniques such as transoral laser microsurgery (TOLMS) or radiation therapy (RT), both providing comparable oncological outcomes but differing in functional results. Local recurrence occurs in approximately 10% of cases, making salvage surgery a crucial therapeutic option. This multi-institutional study investigates the efficacy of open partial horizontal laryngectomy (OPHL) as a salvage treatment, following recurrent laryngeal squamous-cell carcinoma (LSCC) after failed TOLMS. This analysis includes 66 patients who underwent OPHL between 1995 and 2017, reporting favorable oncological outcomes with overall survival (OS) of 87.4%, disease-specific survival (DSS) of 93.4%, and disease-free survival (DFS) of 85.5%. A recurrence rate of 10.6% was observed post-salvage OPHL, with vascular invasion and advanced pathological staging identified as significant predictors of recurrence. OPHL emerged as an effective organ-preserving alternative to total laryngectomy (TL) in select patients, especially those with limited tumor spread and preserved laryngeal function. The study highlights the importance of careful patient selection and thorough preoperative assessment to improve outcomes, positioning OPHL as a key option in treating recurrent laryngeal cancer and offering oncological control while preserving laryngeal functions.https://www.mdpi.com/1718-7729/32/1/12laryngeal cancerpartial laryngectomyOPHLlaryngeal preservationlaserrecurrence |
| spellingShingle | Erika Crosetti Andrea Borello Andy Bertolin Izabela Costa Santos Marco Fantini Giulia Arrigoni Ilaria Bertotto Andrea Elio Sprio Fernando Luiz Dias Giuseppe Rizzotto Giovanni Succo Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series Current Oncology laryngeal cancer partial laryngectomy OPHL laryngeal preservation laser recurrence |
| title | Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series |
| title_full | Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series |
| title_fullStr | Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series |
| title_full_unstemmed | Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series |
| title_short | Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series |
| title_sort | open partial horizontal laryngectomy as a conservative salvage treatment for laser recurrent laryngeal cancer a multi institutional series |
| topic | laryngeal cancer partial laryngectomy OPHL laryngeal preservation laser recurrence |
| url | https://www.mdpi.com/1718-7729/32/1/12 |
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