Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>)
Annual epidemics of influenza result in 3–5 million cases of severe illness and more than 600 000 deaths. Severe forms of influenza are usually characterized by vascular endothelial cells damage. Thus, influenza A viruses, including subtypes A(H1N1)pdm09, A(H3N2), as well as highly pathogenic avian...
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| Language: | English |
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Central Research Institute for Epidemiology
2024-12-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/16681/938 |
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| author | Vladimir A. Marchenko Irina N. Zhilinskaya |
| author_facet | Vladimir A. Marchenko Irina N. Zhilinskaya |
| author_sort | Vladimir A. Marchenko |
| collection | DOAJ |
| description | Annual epidemics of influenza result in 3–5 million cases of severe illness and more than 600 000 deaths. Severe forms of influenza are usually characterized by vascular endothelial cells damage. Thus, influenza A viruses, including subtypes A(H1N1)pdm09, A(H3N2), as well as highly pathogenic avian influenza viruses, can infect the vascular endothelium, leading to activation and subsequent dysfunction of these cells. In turn, endothelial dysfunction resulting in systemic morphofunctional changes of endothelial cells, which leads to impaired vascular tone, thrombosis and other complications, and is also a risk factor and profoundly implicated in the pathogenesis of many cardiovascular diseases. Thus, endothelial dysfunction is an important aspect of the pathogenesis of severe influenza, which must be considered in the pathogenetic therapy of this infectious disease.
The aim of the review is to analyze the causes and specify mechanisms of development of endothelial activation and dysfunction caused by influenza A virus. |
| format | Article |
| id | doaj-art-0813cb7121b44a398a516604794a0a74 |
| institution | Kabale University |
| issn | 0507-4088 2411-2097 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj-art-0813cb7121b44a398a516604794a0a742025-01-22T15:18:43ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972024-12-0169646547810.36233/0507-4088-2641250Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>)Vladimir A. Marchenko0https://orcid.org/0000-0001-6870-3157Irina N. Zhilinskaya1https://orcid.org/0000-0002-0084-1323North-Western State Medical University Named after I.I. MechnikovNorth-Western State Medical University Named after I.I. MechnikovAnnual epidemics of influenza result in 3–5 million cases of severe illness and more than 600 000 deaths. Severe forms of influenza are usually characterized by vascular endothelial cells damage. Thus, influenza A viruses, including subtypes A(H1N1)pdm09, A(H3N2), as well as highly pathogenic avian influenza viruses, can infect the vascular endothelium, leading to activation and subsequent dysfunction of these cells. In turn, endothelial dysfunction resulting in systemic morphofunctional changes of endothelial cells, which leads to impaired vascular tone, thrombosis and other complications, and is also a risk factor and profoundly implicated in the pathogenesis of many cardiovascular diseases. Thus, endothelial dysfunction is an important aspect of the pathogenesis of severe influenza, which must be considered in the pathogenetic therapy of this infectious disease. The aim of the review is to analyze the causes and specify mechanisms of development of endothelial activation and dysfunction caused by influenza A virus.https://virusjour.crie.ru/jour/article/viewFile/16681/938influenza a virusespathogenesis of influenza virus infectionendothelial activationendothelial dysfunctioncardio-vascular system |
| spellingShingle | Vladimir A. Marchenko Irina N. Zhilinskaya Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>) Вопросы вирусологии influenza a viruses pathogenesis of influenza virus infection endothelial activation endothelial dysfunction cardio-vascular system |
| title | Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>) |
| title_full | Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>) |
| title_fullStr | Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>) |
| title_full_unstemmed | Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>) |
| title_short | Endothelial activation and dysfunction caused by influenza A virus (<i>Alphainfluenzavirus influenzae</i>) |
| title_sort | endothelial activation and dysfunction caused by influenza a virus i alphainfluenzavirus influenzae i |
| topic | influenza a viruses pathogenesis of influenza virus infection endothelial activation endothelial dysfunction cardio-vascular system |
| url | https://virusjour.crie.ru/jour/article/viewFile/16681/938 |
| work_keys_str_mv | AT vladimiramarchenko endothelialactivationanddysfunctioncausedbyinfluenzaavirusialphainfluenzavirusinfluenzaei AT irinanzhilinskaya endothelialactivationanddysfunctioncausedbyinfluenzaavirusialphainfluenzavirusinfluenzaei |