Cytokines as cellular communicators
Cytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse regulation of cytokine activity. The activity of cy...
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| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1996-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935196000579 |
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| _version_ | 1832556932741726208 |
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| author | R. Debets H. F. J. Savelkoul |
| author_facet | R. Debets H. F. J. Savelkoul |
| author_sort | R. Debets |
| collection | DOAJ |
| description | Cytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse regulation of cytokine activity. The activity of cytokines is controlled at the level of transcription, translation, storage, processing, posttranslational modification, trapping, binding by soluble proteins, and receptor number and/or function. Translation of this diverse regulation in strategies aimed at the control of cytokine activity will result in the development of more specific and selective drugs to treat diseases. |
| format | Article |
| id | doaj-art-080c955f6a1d48f28a337abcd4663bdb |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-080c955f6a1d48f28a337abcd4663bdb2025-02-03T05:44:05ZengWileyMediators of Inflammation0962-93511466-18611996-01-015641742310.1155/S0962935196000579Cytokines as cellular communicatorsR. Debets0H. F. J. Savelkoul1Department of Immunology, Erasmus University, P.O. Box 1738, Rotterdam 3000 DR, The NetherlandsDepartment of Immunology, Erasmus University, P.O. Box 1738, Rotterdam 3000 DR, The NetherlandsCytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse regulation of cytokine activity. The activity of cytokines is controlled at the level of transcription, translation, storage, processing, posttranslational modification, trapping, binding by soluble proteins, and receptor number and/or function. Translation of this diverse regulation in strategies aimed at the control of cytokine activity will result in the development of more specific and selective drugs to treat diseases.http://dx.doi.org/10.1155/S0962935196000579 |
| spellingShingle | R. Debets H. F. J. Savelkoul Cytokines as cellular communicators Mediators of Inflammation |
| title | Cytokines as cellular communicators |
| title_full | Cytokines as cellular communicators |
| title_fullStr | Cytokines as cellular communicators |
| title_full_unstemmed | Cytokines as cellular communicators |
| title_short | Cytokines as cellular communicators |
| title_sort | cytokines as cellular communicators |
| url | http://dx.doi.org/10.1155/S0962935196000579 |
| work_keys_str_mv | AT rdebets cytokinesascellularcommunicators AT hfjsavelkoul cytokinesascellularcommunicators |