Astrocytes Control Neuronal Excitability in the Nucleus Accumbens
Though accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood. In this review, we will discuss recent results showing that mGluR5 recep...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.195 |
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| _version_ | 1832551579154120704 |
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| author | Tommaso Fellin Marcello D'Ascenzo Philip G. Haydon |
| author_facet | Tommaso Fellin Marcello D'Ascenzo Philip G. Haydon |
| author_sort | Tommaso Fellin |
| collection | DOAJ |
| description | Though accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood. In this review, we will discuss recent results showing that mGluR5 receptors are key regulators of astrocyte activity. Synaptic release of glutamate activates mGluR5 expressed in perisynaptic astrocytes and generates intense Ca2+ signaling in these cells. Ca2+ oscillations, in turn, trigger the release from astrocytes of the gliotransmitter glutamate, which modulates neuronal excitability by activating NMDA receptors. By integrating these results with the most recent evidence demonstrating the importance of astrocytes in the regulation of neuronal excitability, we propose that astrocytes are involved in mediating some of the mGluR5-dependent drug-induced behaviors. |
| format | Article |
| id | doaj-art-08056a81e3d94752973b715d904db3c9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-08056a81e3d94752973b715d904db3c92025-02-03T06:01:08ZengWileyThe Scientific World Journal1537-744X2007-01-017899710.1100/tsw.2007.195Astrocytes Control Neuronal Excitability in the Nucleus AccumbensTommaso Fellin0Marcello D'Ascenzo1Philip G. Haydon2Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAInstitute of Human Physiology, Catholic University, Largo Francesco Vito 1, 00168 Roma, ItalyDepartment of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAThough accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood. In this review, we will discuss recent results showing that mGluR5 receptors are key regulators of astrocyte activity. Synaptic release of glutamate activates mGluR5 expressed in perisynaptic astrocytes and generates intense Ca2+ signaling in these cells. Ca2+ oscillations, in turn, trigger the release from astrocytes of the gliotransmitter glutamate, which modulates neuronal excitability by activating NMDA receptors. By integrating these results with the most recent evidence demonstrating the importance of astrocytes in the regulation of neuronal excitability, we propose that astrocytes are involved in mediating some of the mGluR5-dependent drug-induced behaviors.http://dx.doi.org/10.1100/tsw.2007.195 |
| spellingShingle | Tommaso Fellin Marcello D'Ascenzo Philip G. Haydon Astrocytes Control Neuronal Excitability in the Nucleus Accumbens The Scientific World Journal |
| title | Astrocytes Control Neuronal Excitability in the Nucleus Accumbens |
| title_full | Astrocytes Control Neuronal Excitability in the Nucleus Accumbens |
| title_fullStr | Astrocytes Control Neuronal Excitability in the Nucleus Accumbens |
| title_full_unstemmed | Astrocytes Control Neuronal Excitability in the Nucleus Accumbens |
| title_short | Astrocytes Control Neuronal Excitability in the Nucleus Accumbens |
| title_sort | astrocytes control neuronal excitability in the nucleus accumbens |
| url | http://dx.doi.org/10.1100/tsw.2007.195 |
| work_keys_str_mv | AT tommasofellin astrocytescontrolneuronalexcitabilityinthenucleusaccumbens AT marcellodascenzo astrocytescontrolneuronalexcitabilityinthenucleusaccumbens AT philipghaydon astrocytescontrolneuronalexcitabilityinthenucleusaccumbens |