Long-term effectiveness and safety of methotrexate-tacrolimus combination therapy versus methotrexate monotherapy in reducing rheumatoid arthritis flares after TNF inhibitor discontinuation: a retrospective cohort study

Long-term effectiveness and safety of methotrexate-tacrolimus combination therapy versus methotrexate monotherapy in reducing rheumatoid arthritis flares after TNF inhibitor discontinuation: a retrospective cohort study

Abstract Background This study evaluates the long-term effectiveness and safety of methotrexate-tacrolimus combination therapy compared to methotrexate monotherapy in maintaining successful tumor necrosis factor (TNF) inhibitor discontinuation in rheumatoid arthritis (RA) patients. Methods We retros...

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Bibliographic Details
Main Authors: Taio Naniwa, Mikiko Kajiura
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Rheumatology
Subjects:
Biological therapy
Clinical remission
Recurrence
Rheumatoid arthritis
Withdrawing treatment
Online Access:https://doi.org/10.1186/s41927-025-00489-9
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https://doi.org/10.1186/s41927-025-00489-9

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