Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery
Responsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) up...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2016/1219469 |
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| author | O. Yassine E. Q. Li A. Alfadhel A. Zaher M. Kavaldzhiev S. T. Thoroddsen J. Kosel |
| author_facet | O. Yassine E. Q. Li A. Alfadhel A. Zaher M. Kavaldzhiev S. T. Thoroddsen J. Kosel |
| author_sort | O. Yassine |
| collection | DOAJ |
| description | Responsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500 µm at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method. |
| format | Article |
| id | doaj-art-07f2cef05d5246188f24d3678654b1f4 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-07f2cef05d5246188f24d3678654b1f42025-02-03T05:54:15ZengWileyInternational Journal of Polymer Science1687-94221687-94302016-01-01201610.1155/2016/12194691219469Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug DeliveryO. Yassine0E. Q. Li1A. Alfadhel2A. Zaher3M. Kavaldzhiev4S. T. Thoroddsen5J. Kosel6Computer, Electrical and Mathematical Sciences & Engineering Division, King Abdullah University of Science and Technology, P.O. Box 4700, Thuwal 23955-6900, Saudi ArabiaPhysical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi ArabiaComputer, Electrical and Mathematical Sciences & Engineering Division, King Abdullah University of Science and Technology, P.O. Box 4700, Thuwal 23955-6900, Saudi ArabiaSchool of Engineering, University of British Columbia, 3333 University Way, Kelowna, BC, V1V 1V7, CanadaComputer, Electrical and Mathematical Sciences & Engineering Division, King Abdullah University of Science and Technology, P.O. Box 4700, Thuwal 23955-6900, Saudi ArabiaPhysical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi ArabiaComputer, Electrical and Mathematical Sciences & Engineering Division, King Abdullah University of Science and Technology, P.O. Box 4700, Thuwal 23955-6900, Saudi ArabiaResponsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500 µm at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method.http://dx.doi.org/10.1155/2016/1219469 |
| spellingShingle | O. Yassine E. Q. Li A. Alfadhel A. Zaher M. Kavaldzhiev S. T. Thoroddsen J. Kosel Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery International Journal of Polymer Science |
| title | Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery |
| title_full | Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery |
| title_fullStr | Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery |
| title_full_unstemmed | Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery |
| title_short | Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery |
| title_sort | magnetically triggered monodispersed nanocomposite fabricated by microfluidic approach for drug delivery |
| url | http://dx.doi.org/10.1155/2016/1219469 |
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