Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach
The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targete...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/1/102 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587687559692288 |
|---|---|
| author | Yedi Herdiana Yoga Windhu Wardhana Insan Sunan Kurniawansyah Dolih Gozali Nasrul Wathoni Ferry Ferdiansyah Sofian |
| author_facet | Yedi Herdiana Yoga Windhu Wardhana Insan Sunan Kurniawansyah Dolih Gozali Nasrul Wathoni Ferry Ferdiansyah Sofian |
| author_sort | Yedi Herdiana |
| collection | DOAJ |
| description | The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines. Nanoparticle drug delivery enhances biological availability and delivery to targets, which may increase therapeutic efficacy and decrease general toxicity. The preventive approach again cannot be ignored, mainly keeping up certain modifications in diet and weight, along with pharmacological therapies to reduce uric acid (UA) levels and to decrease the frequency of acute attacks. The advancement of genetic profiling of patients and biomarker discoveries drives the trend towards building individualized medicine and care, quickly gaining ground as the most effective method of delivering treatments to individual patients, moving away from one-size-fits-all treatments. The following paper aims to provide an updated account of the management of gout with a focus on recent developments, in order to enhance these approaches, the quality of life for patients with gout, and the standard of gout treatment. |
| format | Article |
| id | doaj-art-07e8533bfd7947aeadebe192fd987107 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-07e8533bfd7947aeadebe192fd9871072025-01-24T13:45:58ZengMDPI AGPharmaceutics1999-49232025-01-0117110210.3390/pharmaceutics17010102Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems ApproachYedi Herdiana0Yoga Windhu Wardhana1Insan Sunan Kurniawansyah2Dolih Gozali3Nasrul Wathoni4Ferry Ferdiansyah Sofian5Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, IndonesiaThe deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines. Nanoparticle drug delivery enhances biological availability and delivery to targets, which may increase therapeutic efficacy and decrease general toxicity. The preventive approach again cannot be ignored, mainly keeping up certain modifications in diet and weight, along with pharmacological therapies to reduce uric acid (UA) levels and to decrease the frequency of acute attacks. The advancement of genetic profiling of patients and biomarker discoveries drives the trend towards building individualized medicine and care, quickly gaining ground as the most effective method of delivering treatments to individual patients, moving away from one-size-fits-all treatments. The following paper aims to provide an updated account of the management of gout with a focus on recent developments, in order to enhance these approaches, the quality of life for patients with gout, and the standard of gout treatment.https://www.mdpi.com/1999-4923/17/1/102preventive approachnanoparticle delivery systemslifestyle modificationuric acidquality of life |
| spellingShingle | Yedi Herdiana Yoga Windhu Wardhana Insan Sunan Kurniawansyah Dolih Gozali Nasrul Wathoni Ferry Ferdiansyah Sofian Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach Pharmaceutics preventive approach nanoparticle delivery systems lifestyle modification uric acid quality of life |
| title | Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach |
| title_full | Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach |
| title_fullStr | Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach |
| title_full_unstemmed | Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach |
| title_short | Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach |
| title_sort | current status of gout arthritis current approaches to gout arthritis treatment nanoparticles delivery systems approach |
| topic | preventive approach nanoparticle delivery systems lifestyle modification uric acid quality of life |
| url | https://www.mdpi.com/1999-4923/17/1/102 |
| work_keys_str_mv | AT yediherdiana currentstatusofgoutarthritiscurrentapproachestogoutarthritistreatmentnanoparticlesdeliverysystemsapproach AT yogawindhuwardhana currentstatusofgoutarthritiscurrentapproachestogoutarthritistreatmentnanoparticlesdeliverysystemsapproach AT insansunankurniawansyah currentstatusofgoutarthritiscurrentapproachestogoutarthritistreatmentnanoparticlesdeliverysystemsapproach AT dolihgozali currentstatusofgoutarthritiscurrentapproachestogoutarthritistreatmentnanoparticlesdeliverysystemsapproach AT nasrulwathoni currentstatusofgoutarthritiscurrentapproachestogoutarthritistreatmentnanoparticlesdeliverysystemsapproach AT ferryferdiansyahsofian currentstatusofgoutarthritiscurrentapproachestogoutarthritistreatmentnanoparticlesdeliverysystemsapproach |