BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain

BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain

BackgroundBone cancer pain (BCP) significantly impacts patients’ overall quality of life. Cellular energy metabolism homeostasis is critically dependent on mitochondrial integrity, and emerging evidence suggests that mitochondrial dysfunction in chronic BCP exacerbates pain progression by disrupting...

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Bibliographic Details
Main Authors: Mingming Xie, Dan Li, Haohao Zeng, Yulin Huang, Rui Xu, Zhen Wang, Jiacheng Yu, Yu’e Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
bone cancer pain
Mas-related G protein-coupled receptor C
BAM8-22
mitochondrial dysfunction
mitochondrial unfolded protein response
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1575733/full
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