Engineered <i>Escherichia coli</i> Nissle 1917 Expressing IGF1 and FGF19 Reduce Liver Fat Accumulation and Restore Microbial Equilibrium in a Metabolic Dysfunction-Associated Steatotic Liver Disease Mice Model

Engineered <i>Escherichia coli</i> Nissle 1917 Expressing IGF1 and FGF19 Reduce Liver Fat Accumulation and Restore Microbial Equilibrium in a Metabolic Dysfunction-Associated Steatotic Liver Disease Mice Model

Background and objectives: Endocrine dysregulation and intestinal microbiota unbalance are commonly associated with metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to investigate the effectiveness of engineered probiotic <i>Escherichia coli</i> Nissle (EcN) 191...

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Bibliographic Details
Main Authors: Johnson Lok, Valeria Iannone, Carlos Gómez-Gallego, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer, Marjukka Kolehmainen, Hani El-Nezami
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Proceedings
Subjects:
advanced microbial therapeutics
metabolic dysfunction-associated steatotic liver disease
metabolic disease
gut microbiome
Online Access:https://www.mdpi.com/2504-3900/91/1/402
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