SPDEF ameliorates UUO-induced renal fibrosis by transcriptional activation of NR4A1

SPDEF ameliorates UUO-induced renal fibrosis by transcriptional activation of NR4A1

Abstract Nuclear receptor 4A1 (NR4A1) is a gene that increases the likelihood of chronic kidney disease (CKD) and contributes to its development. Previous research has shown that the SAM pointed domain containing Ets transformation-specific transcription factor (SPDEF) can activate NR4A1, but its me...

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Bibliographic Details
Main Authors: Hongshuang Wang, Ziheng Wei, Chang Xu, Fang Fang, Zheng Wang, Yan Zhong, Xiangting Wang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Chronic kidney disease
NR4A1
SPDEF
Renal fibrosis
Online Access:https://doi.org/10.1186/s10020-024-01030-3
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