Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study

Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study

ABSTRACT Background Quercetin is a natural product with multiple activities, which possesses a promising antitumor effect on malignancies. The involvement of proline 4‐hydroxylase II (P4HA2) in collagen synthesis is crucial in the growth of tumor cells. Apoptosis is a programmed cell death requisite...

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Bibliographic Details
Main Authors: Junli Zhang, Jiayi Guo, Ying Qian, Lianchen Yu, Junrao Ma, Biao Gu, Weichun Tang, Yi Li, Hongwei Li, Wenjuan Wu
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Cancer Reports
Subjects:
apoptosis
hepatocellular carcinoma
P4HA2
quercetin
Online Access:https://doi.org/10.1002/cnr2.70220
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