Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2017/4207656 |
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| author | Jocelyn Nugroho Bahareh Schweiger |
| author_facet | Jocelyn Nugroho Bahareh Schweiger |
| author_sort | Jocelyn Nugroho |
| collection | DOAJ |
| description | Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne. Physical exam showed resting tremors, bilateral proptosis, hyperactivity, and rapid speech. A diagnosis of Graves’ Disease was made by correlating symptoms, physical exam findings, ultrasound, and positive family history of autoimmune thyroid disease. Conclusion. Emergence of autoimmune thyroid diseases depends upon genetic predisposition and environmental triggers. Mechanism of action for isotretinoin is not known but the drug may play a role in triggering autoimmunity in genetically susceptible individuals. |
| format | Article |
| id | doaj-art-07bb15abdd234fc5a6ab1cca30e93f99 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-07bb15abdd234fc5a6ab1cca30e93f992025-02-03T01:10:03ZengWileyCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/42076564207656Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible PatientsJocelyn Nugroho0Bahareh Schweiger1Western University of Health Sciences, 309 E 2nd St, Pomona, CA 91766, USACedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USAIntroduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne. Physical exam showed resting tremors, bilateral proptosis, hyperactivity, and rapid speech. A diagnosis of Graves’ Disease was made by correlating symptoms, physical exam findings, ultrasound, and positive family history of autoimmune thyroid disease. Conclusion. Emergence of autoimmune thyroid diseases depends upon genetic predisposition and environmental triggers. Mechanism of action for isotretinoin is not known but the drug may play a role in triggering autoimmunity in genetically susceptible individuals.http://dx.doi.org/10.1155/2017/4207656 |
| spellingShingle | Jocelyn Nugroho Bahareh Schweiger Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients Case Reports in Pediatrics |
| title | Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients |
| title_full | Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients |
| title_fullStr | Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients |
| title_full_unstemmed | Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients |
| title_short | Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients |
| title_sort | isotretinoin as a possible environmental trigger to autoimmunity in genetically susceptible patients |
| url | http://dx.doi.org/10.1155/2017/4207656 |
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