Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy
Abstract Tongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients....
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-024-00343-7 |
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| author | Ming Hao Xingchen Li Xinxin Zhang Boqiang Tao He Shi Jianing Wu Yuyang Li Xiang Li Shuangji Li Han Wu Jingcheng Xiang Dongxu Wang Weiwei Liu Guoqing Wang |
| author_facet | Ming Hao Xingchen Li Xinxin Zhang Boqiang Tao He Shi Jianing Wu Yuyang Li Xiang Li Shuangji Li Han Wu Jingcheng Xiang Dongxu Wang Weiwei Liu Guoqing Wang |
| author_sort | Ming Hao |
| collection | DOAJ |
| description | Abstract Tongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients. The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy. Nanoparticles with diagnostic and photothermal therapeutic properties may offer a new approach for the targeted therapy of TSCC. However, inadequate accumulation of photosensitizers at the tumor site diminishes the efficacy of photothermal therapy (PTT). This study modified gold nanodots (AuNDs) with the TSCC-targeting peptide HN-1 to improve the selectivity and therapeutic effects of PTT. The Au-HN-1 nanosystem effectively targeted the TSCC cells and was rapidly delivered to the tumor tissues compared to the AuNDs. The enhanced accumulation of photosensitizing agents at tumor sites achieved significant PTT effects in a mouse model of TSCC. Moreover, owing to its stable long-term fluorescence and high X-ray attenuation coefficient, the Au-HN-1 nanosystem can be used for fluorescence and computed tomography imaging of TSCC, rendering it useful for early tumor detection and accurate delineation of surgical margins. In conclusion, Au-HN-1 represents a promising nanomedicine for imaging-based diagnosis and targeted PTT of TSCC. |
| format | Article |
| id | doaj-art-07b9eac231144e36aa40f4f4042d7cbf |
| institution | Kabale University |
| issn | 2049-3169 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj-art-07b9eac231144e36aa40f4f4042d7cbf2025-01-19T12:12:32ZengNature Publishing GroupInternational Journal of Oral Science2049-31692025-01-0117111010.1038/s41368-024-00343-7Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapyMing Hao0Xingchen Li1Xinxin Zhang2Boqiang Tao3He Shi4Jianing Wu5Yuyang Li6Xiang Li7Shuangji Li8Han Wu9Jingcheng Xiang10Dongxu Wang11Weiwei Liu12Guoqing Wang13Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityState Key Laboratory of Supramolecular Structure and Material, College of Chemistry, Jilin UniversityLaboratory Animal Center, College of Animal Science, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityLaboratory Animal Center, College of Animal Science, Jilin UniversityDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin UniversityState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Basic Medical Science, Jilin UniversityAbstract Tongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients. The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy. Nanoparticles with diagnostic and photothermal therapeutic properties may offer a new approach for the targeted therapy of TSCC. However, inadequate accumulation of photosensitizers at the tumor site diminishes the efficacy of photothermal therapy (PTT). This study modified gold nanodots (AuNDs) with the TSCC-targeting peptide HN-1 to improve the selectivity and therapeutic effects of PTT. The Au-HN-1 nanosystem effectively targeted the TSCC cells and was rapidly delivered to the tumor tissues compared to the AuNDs. The enhanced accumulation of photosensitizing agents at tumor sites achieved significant PTT effects in a mouse model of TSCC. Moreover, owing to its stable long-term fluorescence and high X-ray attenuation coefficient, the Au-HN-1 nanosystem can be used for fluorescence and computed tomography imaging of TSCC, rendering it useful for early tumor detection and accurate delineation of surgical margins. In conclusion, Au-HN-1 represents a promising nanomedicine for imaging-based diagnosis and targeted PTT of TSCC.https://doi.org/10.1038/s41368-024-00343-7 |
| spellingShingle | Ming Hao Xingchen Li Xinxin Zhang Boqiang Tao He Shi Jianing Wu Yuyang Li Xiang Li Shuangji Li Han Wu Jingcheng Xiang Dongxu Wang Weiwei Liu Guoqing Wang Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy International Journal of Oral Science |
| title | Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy |
| title_full | Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy |
| title_fullStr | Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy |
| title_full_unstemmed | Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy |
| title_short | Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy |
| title_sort | tongue squamous cell carcinoma targeting au hn 1 nanosystem for ct imaging and photothermal therapy |
| url | https://doi.org/10.1038/s41368-024-00343-7 |
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