A Case of Onychomycosis Caused by Rhodotorula glutinis
Rhodotorula spp. have emerged as opportunistic pathogens, particularly in immunocompromised patients. The current study reports a case of onychomycosis caused by Rhodotorula glutinis in a 74-year-old immunocompetent female. The causative agent was identified as R. glutinis based on the pinkish-orang...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/563261 |
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| author | Hatice Uludag Altun Tuba Meral Emel Turk Aribas Canan Gorpelioglu Nilgun Karabicak |
| author_facet | Hatice Uludag Altun Tuba Meral Emel Turk Aribas Canan Gorpelioglu Nilgun Karabicak |
| author_sort | Hatice Uludag Altun |
| collection | DOAJ |
| description | Rhodotorula spp. have emerged as opportunistic pathogens, particularly in immunocompromised patients. The current study reports a case of onychomycosis caused by Rhodotorula glutinis in a 74-year-old immunocompetent female. The causative agent was identified as R. glutinis based on the pinkish-orange color; mucoid-appearing yeast colonies on Sabouraud Dextrose Agar at 25°C; morphological evaluation in the Corn Meal-Tween 80 agar; observed oval/round budding yeast at 25°C for 72 hours; no observed pseudohyphae; positive urease activity at 25°C for 4 days; and assimilation features detected by API ID 32C kit and automated Vitek Yeast Biochemical Card 2 system. Antifungal susceptibility test results were as follows: amphotericin B (MIC = 0.5 µg/mL), fluconazole (MIC = 128 µg/mL), itraconazole (MIC = 0.125 µg/mL), voriconazole (MIC = 1 µg/mL), posaconazole (MIC = 0.5 µg/mL), anidulafungin (MIC = 0.5 µg/mL), and caspofungin (MIC = 16 µg/mL). Antifungal therapy was initiated with oral itraconazole at a dose of 400 mg/day; seven-day pulse therapy was planned at intervals of three weeks. Clinical recovery was observed in the clinical evaluation of the patient before the start of the third cure. Although R. glutinis has rarely been reported as the causative agent of onychomycosis, it should be considered. |
| format | Article |
| id | doaj-art-07b53e413c5540e989145604fc78ca46 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-07b53e413c5540e989145604fc78ca462025-02-03T05:48:03ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712014-01-01201410.1155/2014/563261563261A Case of Onychomycosis Caused by Rhodotorula glutinisHatice Uludag Altun0Tuba Meral1Emel Turk Aribas2Canan Gorpelioglu3Nilgun Karabicak4Department of Clinical Microbiology, Faculty of Medicine, Turgut Ozal University, Emek, 06510 Ankara, TurkeyDepartment of Clinical Microbiology, Faculty of Medicine, Turgut Ozal University, Emek, 06510 Ankara, TurkeyDepartment of Clinical Microbiology, Faculty of Medicine, Turgut Ozal University, Emek, 06510 Ankara, TurkeyDepartment of Dermatology, Faculty of Medicine, Turgut Ozal University, Emek, 06510 Ankara, TurkeyMycology Reference Laboratory, Public Health Institution of Turkey, Sıhhıye, 06100 Ankara, TurkeyRhodotorula spp. have emerged as opportunistic pathogens, particularly in immunocompromised patients. The current study reports a case of onychomycosis caused by Rhodotorula glutinis in a 74-year-old immunocompetent female. The causative agent was identified as R. glutinis based on the pinkish-orange color; mucoid-appearing yeast colonies on Sabouraud Dextrose Agar at 25°C; morphological evaluation in the Corn Meal-Tween 80 agar; observed oval/round budding yeast at 25°C for 72 hours; no observed pseudohyphae; positive urease activity at 25°C for 4 days; and assimilation features detected by API ID 32C kit and automated Vitek Yeast Biochemical Card 2 system. Antifungal susceptibility test results were as follows: amphotericin B (MIC = 0.5 µg/mL), fluconazole (MIC = 128 µg/mL), itraconazole (MIC = 0.125 µg/mL), voriconazole (MIC = 1 µg/mL), posaconazole (MIC = 0.5 µg/mL), anidulafungin (MIC = 0.5 µg/mL), and caspofungin (MIC = 16 µg/mL). Antifungal therapy was initiated with oral itraconazole at a dose of 400 mg/day; seven-day pulse therapy was planned at intervals of three weeks. Clinical recovery was observed in the clinical evaluation of the patient before the start of the third cure. Although R. glutinis has rarely been reported as the causative agent of onychomycosis, it should be considered.http://dx.doi.org/10.1155/2014/563261 |
| spellingShingle | Hatice Uludag Altun Tuba Meral Emel Turk Aribas Canan Gorpelioglu Nilgun Karabicak A Case of Onychomycosis Caused by Rhodotorula glutinis Case Reports in Dermatological Medicine |
| title | A Case of Onychomycosis Caused by Rhodotorula glutinis |
| title_full | A Case of Onychomycosis Caused by Rhodotorula glutinis |
| title_fullStr | A Case of Onychomycosis Caused by Rhodotorula glutinis |
| title_full_unstemmed | A Case of Onychomycosis Caused by Rhodotorula glutinis |
| title_short | A Case of Onychomycosis Caused by Rhodotorula glutinis |
| title_sort | case of onychomycosis caused by rhodotorula glutinis |
| url | http://dx.doi.org/10.1155/2014/563261 |
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