Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome
Purpose. To investigate the prognostic significance of endocan, compared with procalcitonin (PCT), C-reactive protein (CRP),white blood cells (WBC), neutrophils (N), and clinical severity scores in patients with ARDS. Methods. A total of 42 patients with ARDS were initially enrolled, and there were...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/625180 |
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| author | Ling Tang Ying Zhao Daoxin Wang Wang Deng Changyi Li Qi Li Shicong Huang Chang Shu |
| author_facet | Ling Tang Ying Zhao Daoxin Wang Wang Deng Changyi Li Qi Li Shicong Huang Chang Shu |
| author_sort | Ling Tang |
| collection | DOAJ |
| description | Purpose. To investigate the prognostic significance of endocan, compared with procalcitonin (PCT), C-reactive protein (CRP),white blood cells (WBC), neutrophils (N), and clinical severity scores in patients with ARDS. Methods. A total of 42 patients with ARDS were initially enrolled, and there were 20 nonsurvivors and 22 survivors based on hospital mortality. Plasma levels of biomarkers were measured and the acute physiology and chronic health evaluation II (APACHE II) was calculated on day 1 after the patient met the defining criteria of ARDS. Results. Endocan levels significantly correlated with the APACHE II score in the ARDS group (r=0.676, P=0.000, n=42). Of 42 individuals with ARDS, 20 were dead, and endocan was significantly higher in nonsurvivors than in survivors (median (IQR) 5.01 (2.98–8.44) versus 3.01 (2.36–4.36) ng/mL, P=0.017). According to the results of the ROC-curve analysis and COX proportional hazards models, endocan can predict mortality of ARDS independently with a hazard ratio of 1.374 (95% CI, 1.150–1.641) and an area of receiver operator characteristic curve (AUROC) of 0.715 (P=0.017). Moreover, endocan can predict the multiple-organ dysfunction of ARDS. Conclusion. Endocan is a promising biomarker to predict the disease severity and mortality in patients with ARDS. |
| format | Article |
| id | doaj-art-07af884377fc4fef8bc5c0c83dc131ac |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-07af884377fc4fef8bc5c0c83dc131ac2025-02-03T01:03:14ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/625180625180Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress SyndromeLing Tang0Ying Zhao1Daoxin Wang2Wang Deng3Changyi Li4Qi Li5Shicong Huang6Chang Shu7Department of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaRespiratory Department, Xinqiao Hospital, Chongqing 400037, ChinaRespiratory Department, First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, ChinaRespiratory Department, Tong Liang County People’s Hospital, Chongqing 402560, ChinaPurpose. To investigate the prognostic significance of endocan, compared with procalcitonin (PCT), C-reactive protein (CRP),white blood cells (WBC), neutrophils (N), and clinical severity scores in patients with ARDS. Methods. A total of 42 patients with ARDS were initially enrolled, and there were 20 nonsurvivors and 22 survivors based on hospital mortality. Plasma levels of biomarkers were measured and the acute physiology and chronic health evaluation II (APACHE II) was calculated on day 1 after the patient met the defining criteria of ARDS. Results. Endocan levels significantly correlated with the APACHE II score in the ARDS group (r=0.676, P=0.000, n=42). Of 42 individuals with ARDS, 20 were dead, and endocan was significantly higher in nonsurvivors than in survivors (median (IQR) 5.01 (2.98–8.44) versus 3.01 (2.36–4.36) ng/mL, P=0.017). According to the results of the ROC-curve analysis and COX proportional hazards models, endocan can predict mortality of ARDS independently with a hazard ratio of 1.374 (95% CI, 1.150–1.641) and an area of receiver operator characteristic curve (AUROC) of 0.715 (P=0.017). Moreover, endocan can predict the multiple-organ dysfunction of ARDS. Conclusion. Endocan is a promising biomarker to predict the disease severity and mortality in patients with ARDS.http://dx.doi.org/10.1155/2014/625180 |
| spellingShingle | Ling Tang Ying Zhao Daoxin Wang Wang Deng Changyi Li Qi Li Shicong Huang Chang Shu Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome Mediators of Inflammation |
| title | Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome |
| title_full | Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome |
| title_fullStr | Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome |
| title_full_unstemmed | Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome |
| title_short | Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome |
| title_sort | endocan levels in peripheral blood predict outcomes of acute respiratory distress syndrome |
| url | http://dx.doi.org/10.1155/2014/625180 |
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