Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies
Cardiac tissue injury and repair have always been a research hotspot in the field of cardiovascular disease. Limited and lost myocardial cells are non-renewable, and the current clinical treatment effect is still poor. The stem cells-based treatment strategy for cardiomyopathy is expected to solve t...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1600604/full |
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| author | Jiali Yang Jiali Yang Tian Yue Jian He Jian He Shiqiang Xiong Yan Luo Jun Hou |
| author_facet | Jiali Yang Jiali Yang Tian Yue Jian He Jian He Shiqiang Xiong Yan Luo Jun Hou |
| author_sort | Jiali Yang |
| collection | DOAJ |
| description | Cardiac tissue injury and repair have always been a research hotspot in the field of cardiovascular disease. Limited and lost myocardial cells are non-renewable, and the current clinical treatment effect is still poor. The stem cells-based treatment strategy for cardiomyopathy is expected to solve the current treatment pain points. A variety of stem cells have the potential to differentiate into cardiomyocytes and form cardiac tissue, and the strong paracrine activity of stem cells also plays an important role in the regulation of inflammation, oxidative stress and cardiomyocyte apoptosis in cardiac tissue. Limited by the survival rate and stem cells activity after stem cells transplantation, the effect of stem cells therapy on cardiomyopathy is still not ideal. Pretreatment of stem cells or genetic modification to enhance the adaptability of stem cells to the environment, or the use of new biomaterials to assist stem cells transplantation is an effective optimization scheme and significantly enhances the therapeutic effect of stem cells therapy for cardiomyopathy. In this review, the types of stem cells widely studied in the treatment of cardiomyopathy, the role of stem cells in the treatment of cardiomyopathy, and how to efficiently use stem cells to treat cardiomyopathy are described in detail, which provides a theoretical basis for promoting the preclinical research and clinical transformation of stem cell therapy for cardiomyopathy. |
| format | Article |
| id | doaj-art-07a8fc72fddb47838f35c204cd883ae5 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-07a8fc72fddb47838f35c204cd883ae52025-08-20T02:07:37ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.16006041600604Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategiesJiali Yang0Jiali Yang1Tian Yue2Jian He3Jian He4Shiqiang Xiong5Yan Luo6Jun Hou7Department of Cardiology, The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu Institute of Cardiovascular Disease, Chengdu, Sichuan, ChinaSchool of life science and engineering, Southwest Jiaotong University, Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu Institute of Cardiovascular Disease, Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu Institute of Cardiovascular Disease, Chengdu, Sichuan, ChinaSchool of life science and engineering, Southwest Jiaotong University, Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu Institute of Cardiovascular Disease, Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu Institute of Cardiovascular Disease, Chengdu, Sichuan, ChinaDepartment of Cardiology, The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu Institute of Cardiovascular Disease, Chengdu, Sichuan, ChinaCardiac tissue injury and repair have always been a research hotspot in the field of cardiovascular disease. Limited and lost myocardial cells are non-renewable, and the current clinical treatment effect is still poor. The stem cells-based treatment strategy for cardiomyopathy is expected to solve the current treatment pain points. A variety of stem cells have the potential to differentiate into cardiomyocytes and form cardiac tissue, and the strong paracrine activity of stem cells also plays an important role in the regulation of inflammation, oxidative stress and cardiomyocyte apoptosis in cardiac tissue. Limited by the survival rate and stem cells activity after stem cells transplantation, the effect of stem cells therapy on cardiomyopathy is still not ideal. Pretreatment of stem cells or genetic modification to enhance the adaptability of stem cells to the environment, or the use of new biomaterials to assist stem cells transplantation is an effective optimization scheme and significantly enhances the therapeutic effect of stem cells therapy for cardiomyopathy. In this review, the types of stem cells widely studied in the treatment of cardiomyopathy, the role of stem cells in the treatment of cardiomyopathy, and how to efficiently use stem cells to treat cardiomyopathy are described in detail, which provides a theoretical basis for promoting the preclinical research and clinical transformation of stem cell therapy for cardiomyopathy.https://www.frontiersin.org/articles/10.3389/fphar.2025.1600604/fullstem cellscardiomyopathycell differentiationparacrine effecthydrogels |
| spellingShingle | Jiali Yang Jiali Yang Tian Yue Jian He Jian He Shiqiang Xiong Yan Luo Jun Hou Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies Frontiers in Pharmacology stem cells cardiomyopathy cell differentiation paracrine effect hydrogels |
| title | Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies |
| title_full | Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies |
| title_fullStr | Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies |
| title_full_unstemmed | Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies |
| title_short | Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies |
| title_sort | stem cells in the treatment of myocardial injury induced cardiomyopathy mechanisms and efficient utilization strategies |
| topic | stem cells cardiomyopathy cell differentiation paracrine effect hydrogels |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1600604/full |
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