Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women
Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resi...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/927805 |
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| author | Nasser M. Rizk Elham Sharif |
| author_facet | Nasser M. Rizk Elham Sharif |
| author_sort | Nasser M. Rizk |
| collection | DOAJ |
| description | Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17–25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R with p values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin. |
| format | Article |
| id | doaj-art-07a868547386439f935fe71b3b93def2 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-07a868547386439f935fe71b3b93def22025-02-03T01:10:23ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/927805927805Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young WomenNasser M. Rizk0Elham Sharif1Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, QatarHealth Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, QatarBackground and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17–25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R with p values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.http://dx.doi.org/10.1155/2015/927805 |
| spellingShingle | Nasser M. Rizk Elham Sharif Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women International Journal of Endocrinology |
| title | Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women |
| title_full | Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women |
| title_fullStr | Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women |
| title_full_unstemmed | Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women |
| title_short | Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women |
| title_sort | leptin as well as free leptin receptor is associated with polycystic ovary syndrome in young women |
| url | http://dx.doi.org/10.1155/2015/927805 |
| work_keys_str_mv | AT nassermrizk leptinaswellasfreeleptinreceptorisassociatedwithpolycysticovarysyndromeinyoungwomen AT elhamsharif leptinaswellasfreeleptinreceptorisassociatedwithpolycysticovarysyndromeinyoungwomen |