Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers
Purpose Evaluate the use of widefield radiation therapy (RT) in the management of extensive skin field cancerization (ESFC) with/without keratinocyte cancer (KC).Methods The National Dermatology Radiation Oncology Registry is a multidisciplinary collaboration (dermatologists and radiation oncologist...
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Taylor & Francis Group
2022-07-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2022.2067814 |
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| author | Andrew E. Potter Christopher Baker Stephen Shumack Robert Sinclair Walter J. Curran David Christie Bradley Wong Peter Foley Peter O’Brien Lynda Spelman |
| author_facet | Andrew E. Potter Christopher Baker Stephen Shumack Robert Sinclair Walter J. Curran David Christie Bradley Wong Peter Foley Peter O’Brien Lynda Spelman |
| author_sort | Andrew E. Potter |
| collection | DOAJ |
| description | Purpose Evaluate the use of widefield radiation therapy (RT) in the management of extensive skin field cancerization (ESFC) with/without keratinocyte cancer (KC).Methods The National Dermatology Radiation Oncology Registry is a multidisciplinary collaboration (dermatologists and radiation oncologists). It captures disease description, prior therapies, radiation prescription, clinical effect, skin cosmesis scores, and toxicity data. This analysis included 12-month follow-up data on 89 treated fields from a subset of 83 patients.Results Clinical success (>90% field clearance) was 96% (ESFC, n = 63) and 88% (ESFC with KC, n = 26). Complete lesion response was seen in 96% of evaluable (n = 25) ESFC with KC. Recurrence (4/89 [5%]) and appearance of new lesions (10/89 [11%]) were minimal. Cosmetic outcome was excellent/good in 98% ESFC and 96% ESFC with KC. Grade 1–2 acute radiation dermatitis occurred in up to 80% of treated fields. The frequency of Grade 3 acute skin toxicities was low.Conclusions Registry data demonstrate the potential for widefield RT to treat patients with significant skin pathology who have exhausted other therapies and require durable, minimally invasive treatment options. At 12 months, observed clinical success rates were higher than those reported for topical interventions for ESFC. Ongoing follow-up is required to determine longer term outcomes. |
| format | Article |
| id | doaj-art-079b17d6ccc7499fba6594a25ec46f56 |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-079b17d6ccc7499fba6594a25ec46f562025-02-05T19:02:55ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-07-013352634264210.1080/09546634.2022.2067814Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancersAndrew E. Potter0Christopher Baker1Stephen Shumack2Robert Sinclair3Walter J. Curran4David Christie5Bradley Wong6Peter Foley7Peter O’Brien8Lynda Spelman9GenesisCare Radiation Oncology, Adelaide, AustraliaDepartment of Dermatology, St Vincent’s Hospital Melbourne, Fitzroy, AustraliaSydney Medical School, University of Sydney, Sydney, AustraliaQueensland Institute of Dermatology, Brisbane, AustraliaOncology, GenesisCare, Fort Myers, FL, USAGenesisCare, Gold Coast, QLD, AustraliaGenesisCare Radiation Oncology, Buderim, QLD, AustraliaDepartment of Dermatology, St Vincent’s Hospital Melbourne, Fitzroy, AustraliaGenesisCare Radiation Oncology, Newcastle, NSW, AustraliaQueensland Institute of Dermatology, Brisbane, AustraliaPurpose Evaluate the use of widefield radiation therapy (RT) in the management of extensive skin field cancerization (ESFC) with/without keratinocyte cancer (KC).Methods The National Dermatology Radiation Oncology Registry is a multidisciplinary collaboration (dermatologists and radiation oncologists). It captures disease description, prior therapies, radiation prescription, clinical effect, skin cosmesis scores, and toxicity data. This analysis included 12-month follow-up data on 89 treated fields from a subset of 83 patients.Results Clinical success (>90% field clearance) was 96% (ESFC, n = 63) and 88% (ESFC with KC, n = 26). Complete lesion response was seen in 96% of evaluable (n = 25) ESFC with KC. Recurrence (4/89 [5%]) and appearance of new lesions (10/89 [11%]) were minimal. Cosmetic outcome was excellent/good in 98% ESFC and 96% ESFC with KC. Grade 1–2 acute radiation dermatitis occurred in up to 80% of treated fields. The frequency of Grade 3 acute skin toxicities was low.Conclusions Registry data demonstrate the potential for widefield RT to treat patients with significant skin pathology who have exhausted other therapies and require durable, minimally invasive treatment options. At 12 months, observed clinical success rates were higher than those reported for topical interventions for ESFC. Ongoing follow-up is required to determine longer term outcomes.https://www.tandfonline.com/doi/10.1080/09546634.2022.2067814Extensive skin field cancerizationkeratinocyte cancerregistryvolumetric modulated arc therapywidefield radiation therapy |
| spellingShingle | Andrew E. Potter Christopher Baker Stephen Shumack Robert Sinclair Walter J. Curran David Christie Bradley Wong Peter Foley Peter O’Brien Lynda Spelman Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers Journal of Dermatological Treatment Extensive skin field cancerization keratinocyte cancer registry volumetric modulated arc therapy widefield radiation therapy |
| title | Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers |
| title_full | Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers |
| title_fullStr | Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers |
| title_full_unstemmed | Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers |
| title_short | Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers |
| title_sort | preliminary efficacy and safety analysis 12 month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers |
| topic | Extensive skin field cancerization keratinocyte cancer registry volumetric modulated arc therapy widefield radiation therapy |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2022.2067814 |
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