An experimental target-based platform in yeast for screening Plasmodium vivax deoxyhypusine synthase inhibitors.

An experimental target-based platform in yeast for screening Plasmodium vivax deoxyhypusine synthase inhibitors.

The enzyme deoxyhypusine synthase (DHS) catalyzes the first step in the post-translational modification of the eukaryotic translation factor 5A (eIF5A). This is the only protein known to contain the amino acid hypusine, which results from this modification. Both eIF5A and DHS are essential for cell...

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Main Authors: Suélen Fernandes Silva, Angélica Hollunder Klippel, Sunniva Sigurdardóttir, Sayyed Jalil Mahdizadeh, Ievgeniia Tiukova, Catarina Bourgard, Luis Carlos Salazar-Alvarez, Heloísa Monteiro do Amaral Prado, Renan Vinicius de Araujo, Fabio Trindade Maranhão Costa, Elizabeth Bilsland, Ross D King, Katlin Brauer Massirer, Leif A Eriksson, Mário Henrique Bengtson, Cleslei Fernando Zanelli, Per Sunnerhagen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012690
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