Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis
Abstract Background Tongue-coating microbiota, especially known as the tongue microbiome, holds significant value as both a prospective clinical diagnostic biomarker and therapeutic target, which plays a crucial role in the oral microecological health. However, there is limited understanding of the...
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BMC
2025-01-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05455-y |
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| author | Qiang Luo Siyuan Chu Yongqun Wu Lingling Jin Rui Liu Yulin Xu Yina Yu Yawei Jin Luckress Ornelle Edouarda Phyfamin Houndekon Heshen Hu Yvchen Zou Hao Huang Haimin Chen |
| author_facet | Qiang Luo Siyuan Chu Yongqun Wu Lingling Jin Rui Liu Yulin Xu Yina Yu Yawei Jin Luckress Ornelle Edouarda Phyfamin Houndekon Heshen Hu Yvchen Zou Hao Huang Haimin Chen |
| author_sort | Qiang Luo |
| collection | DOAJ |
| description | Abstract Background Tongue-coating microbiota, especially known as the tongue microbiome, holds significant value as both a prospective clinical diagnostic biomarker and therapeutic target, which plays a crucial role in the oral microecological health. However, there is limited understanding of the composition and function of tongue coating microbiota in chronic kidney disease patients undergoing hemodialysis. Methods Thirty-one non-diabetic hemodialysis patients (nonDM_HD), 29 diabetic hemodialysis patients (DM_HD) and 33 healthy controls (HC) were enrolled. Swabs from tongue coating were collected. The 16S rDNA (V3-V4 region) was sequenced to scrutinize the tongue-coating bacterial microbiome difference. Results Both nonDM_HD and DM_HD showed distinct bacterial communities of oral microbiota compared to HC. The abundance of Streptococcus, Lactobacillus, Ruminococcaceae G1, Ligilactobacillus and Abiotrophia showed a significant increase (p < 0.05) in DM_HD and nonDM_HD compared to HC, while Haemophilus, Lachnoanaerobaculum, Peptostreptococcaceae G1, Peptostreptococcus showed a significant decrease (p < 0.05) respectively. Veillonella, Lactobacillus, Limosilactobacillus etc. may serve as potential biomarkers for DM_HD. While Streptococcus, Ruminococcaceae G1, Actinobacillus, Abiotrophia can be considered alternative biomarkers for nonDM_HD. Moreover, the enriched Haemophilus, Actinomyces, Lachnoanaerobaculum were prominent features of the tongue coating microbiota in HC, which could be used as the potential therapeutic targets of chronic kidney disease. Network analysis revealed a less complex interaction relationship among the tongue coating bacterial microbiota of nonDM_HD and DM_HD. Furthermore, correlations were identified between the microbiome composition and clinical parameters of the individuals. Conclusion In conclusion, deciphering the tongue coating microbiota of kidney patients undergoing hemodialysis will helpful in assessing the role of oral microbiota in pathobiology and development of kidney disease, which is expected to become a potential biomarkers and adjuvant therapeutic target. |
| format | Article |
| id | doaj-art-078ee3a9639b4697bbbf819d21a727fd |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-078ee3a9639b4697bbbf819d21a727fd2025-01-26T12:55:03ZengBMCBMC Oral Health1472-68312025-01-0125111610.1186/s12903-025-05455-yCharacteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysisQiang Luo0Siyuan Chu1Yongqun Wu2Lingling Jin3Rui Liu4Yulin Xu5Yina Yu6Yawei Jin7Luckress Ornelle Edouarda Phyfamin Houndekon8Heshen Hu9Yvchen Zou10Hao Huang11Haimin Chen12Department of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityDepartment of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineCollege of Life Sciences and Medicine, Zhejiang Sci-Tech UniversityAbstract Background Tongue-coating microbiota, especially known as the tongue microbiome, holds significant value as both a prospective clinical diagnostic biomarker and therapeutic target, which plays a crucial role in the oral microecological health. However, there is limited understanding of the composition and function of tongue coating microbiota in chronic kidney disease patients undergoing hemodialysis. Methods Thirty-one non-diabetic hemodialysis patients (nonDM_HD), 29 diabetic hemodialysis patients (DM_HD) and 33 healthy controls (HC) were enrolled. Swabs from tongue coating were collected. The 16S rDNA (V3-V4 region) was sequenced to scrutinize the tongue-coating bacterial microbiome difference. Results Both nonDM_HD and DM_HD showed distinct bacterial communities of oral microbiota compared to HC. The abundance of Streptococcus, Lactobacillus, Ruminococcaceae G1, Ligilactobacillus and Abiotrophia showed a significant increase (p < 0.05) in DM_HD and nonDM_HD compared to HC, while Haemophilus, Lachnoanaerobaculum, Peptostreptococcaceae G1, Peptostreptococcus showed a significant decrease (p < 0.05) respectively. Veillonella, Lactobacillus, Limosilactobacillus etc. may serve as potential biomarkers for DM_HD. While Streptococcus, Ruminococcaceae G1, Actinobacillus, Abiotrophia can be considered alternative biomarkers for nonDM_HD. Moreover, the enriched Haemophilus, Actinomyces, Lachnoanaerobaculum were prominent features of the tongue coating microbiota in HC, which could be used as the potential therapeutic targets of chronic kidney disease. Network analysis revealed a less complex interaction relationship among the tongue coating bacterial microbiota of nonDM_HD and DM_HD. Furthermore, correlations were identified between the microbiome composition and clinical parameters of the individuals. Conclusion In conclusion, deciphering the tongue coating microbiota of kidney patients undergoing hemodialysis will helpful in assessing the role of oral microbiota in pathobiology and development of kidney disease, which is expected to become a potential biomarkers and adjuvant therapeutic target.https://doi.org/10.1186/s12903-025-05455-y16S rDNA sequencingTongue coating microbiotaChronic kidney diseaseHemodialysisDiabetesBiomarkers |
| spellingShingle | Qiang Luo Siyuan Chu Yongqun Wu Lingling Jin Rui Liu Yulin Xu Yina Yu Yawei Jin Luckress Ornelle Edouarda Phyfamin Houndekon Heshen Hu Yvchen Zou Hao Huang Haimin Chen Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis BMC Oral Health 16S rDNA sequencing Tongue coating microbiota Chronic kidney disease Hemodialysis Diabetes Biomarkers |
| title | Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis |
| title_full | Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis |
| title_fullStr | Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis |
| title_full_unstemmed | Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis |
| title_short | Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis |
| title_sort | characteristics of tongue coating microbiota in diabetic and non diabetic kidney patients receiving hemodialysis |
| topic | 16S rDNA sequencing Tongue coating microbiota Chronic kidney disease Hemodialysis Diabetes Biomarkers |
| url | https://doi.org/10.1186/s12903-025-05455-y |
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