Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease

Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease

A long-standing theory for Alzheimer’s disease (AD) has been that deterioration of synapses and depressed neuronal activity is a major contributing factor. We review the increasing evidence, in humans and in mouse models, that show that there is often neuronal hyperactivity at early stages rather th...

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Bibliographic Details
Main Authors: Helen E. Scharfman, Korey Kam, Áine M. Duffy, John J. LaFrancois, Paige Leary, Elissavet Chartampila, Stephen D. Ginsberg, Christos Panagiotis Lisgaras
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Dementia
Subjects:
cholinergic
muscarinic
memory
amyloid β
mouse model
Tg2576
Online Access:https://www.frontiersin.org/articles/10.3389/frdem.2025.1513144/full
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