Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease
A long-standing theory for Alzheimer’s disease (AD) has been that deterioration of synapses and depressed neuronal activity is a major contributing factor. We review the increasing evidence, in humans and in mouse models, that show that there is often neuronal hyperactivity at early stages rather th...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Dementia |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frdem.2025.1513144/full |
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