The impact of immune cell interactions on virus quasi-species formation
The process of viral infection spreading in tissues was influenced by various factors, including virus replication within host cells, transportation, and the immune response. Reaction-diffusion systems provided a suitable framework for examining this process. In this work, we studied a nonlocal reac...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2024-11-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2024331 |
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| Summary: | The process of viral infection spreading in tissues was influenced by various factors, including virus replication within host cells, transportation, and the immune response. Reaction-diffusion systems provided a suitable framework for examining this process. In this work, we studied a nonlocal reaction-diffusion system of equations that modeled the distribution of viruses based on their genotypes and their interaction with the immune response. It was shown that the infection may persist at a certain level alongside a chronic immune response, exhibiting spatially uniform or oscillatory behavior. Finally, the immune cells may become entirely depleted, leading to a high viral load persisting in the tissue. Numerical simulations were employed to elucidate the nonlinear dynamics and pattern formation inherent in the nonlocal model. |
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| ISSN: | 1551-0018 |